Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Noninvasive Coronary Imaging

02.09.2003


ESC Congress 2003: Picture Perfect – Progress in non-invasive imaging



There has been increasing awareness of the importance of composition of athero-thrombotic plaque as a major risk factor for acute coronary syndromes. Several invasive and noninvasive imaging techniques are available to assess athero-thrombotic vessels.

Most of the standard techniques identify luminal diameter or stenosis, wall thickness, or plaque volume (such as multi-slice CT, angiography, IVUS, etc.); however, none are effective in determining the plaques that are unstable and vulnerable to thrombosis and proliferation. In vivo, high-resolution, multi-contrast, magnetic resonance imaging (MRI) holds the best promise of non-invasively imaging vulnerable plaques and determination of the different plaque components such as lipid core, fibrosis, calcifications and thrombosis deposits in all arteries including the coronary arteries.


The MR findings have been extensively validated against pathology in ex vivo studies of carotid, aortic, and coronary artery specimens obtained at autopsy. Subsequent work on imaging carotid arteries in vivo in patients referred for endarterectomy showed a high correlation with pathology and with previous ex vivo results.

A recent study in patients with plaques in the thoracic aorta showed that when compared to transesophageal echocardiography, plaque composition and size are accurately characterized and measured using in vivo MRI. Carotid and aortic athero-thrombotic plaque assessment by MRI may lend itself to use as a screening tool for prediction of future cardiovascular events and for the evaluation of therapeutic intervention benefits.

These MR techniques have been also adapted for the study of plaques in different animal models. Therefore, MRI can be used as an investigative to follow in vivo progression, regression and plaque stabilization in different transgenic and non-transgenic animal models.

The ultimate goal is imaging of plaque in vivo in human coronary arteries. Preliminary studies in a porcine model of athero-thrombosis showed that the major difficulties of MR coronary wall imaging are due to the combination of cardiac and respiratory motion artifacts, the non-linear course of the coronary arteries, as well as their relatively small size and location.

Studies in an in-vivo pig model and in humans suggest that MRI may soon be applicable to study and characterize athero-thrombotic plaques in human coronaries in vivo. We have shown recently the utility of MRI in the study of treatment in humans. MR was used to measure the effect of lipid-lowering therapy (statins) in asymptomatic untreated hypercholesterolemic patients with carotid and aortic atherosclerosis.

In conclusion, the assessment of athero-thrombotic plaques by imaging techniques is essential for the identification of vulnerable plaques. In vivo, high-resolution, multi-contrast, MRI holds the best promise of non-invasively imaging vulnerable plaques and characterizing the different components in all arteries including the coronary arteries. MR allows serial evaluation assessment of the progression and regression of atherosclerosis over time. The use of specific MR contrast agents targeted for athero-thrombotic plaque imaging may enhance the plaque characterization. Application of MRI opens new areas for diagnosis, prevention, and treatment (e.g., lipid-lowering drug regimens) of athero-thrombosis in all arterial locations.

Roberto Corti, MD
Cardiology, University Hospital Zurich
Switzerland

Important: This press release accompanies both a presentation and an ESC press conference given at the ESC Congress 2003. Written by the investigator himself/herself, this press release does not necessarily reflect the opinion of the European Society of Cardiology


Camilla Dormer | alfa
Further information:
http://www.escardio.org

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>