Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Noninvasive Coronary Imaging

02.09.2003


ESC Congress 2003: Picture Perfect – Progress in non-invasive imaging



There has been increasing awareness of the importance of composition of athero-thrombotic plaque as a major risk factor for acute coronary syndromes. Several invasive and noninvasive imaging techniques are available to assess athero-thrombotic vessels.

Most of the standard techniques identify luminal diameter or stenosis, wall thickness, or plaque volume (such as multi-slice CT, angiography, IVUS, etc.); however, none are effective in determining the plaques that are unstable and vulnerable to thrombosis and proliferation. In vivo, high-resolution, multi-contrast, magnetic resonance imaging (MRI) holds the best promise of non-invasively imaging vulnerable plaques and determination of the different plaque components such as lipid core, fibrosis, calcifications and thrombosis deposits in all arteries including the coronary arteries.


The MR findings have been extensively validated against pathology in ex vivo studies of carotid, aortic, and coronary artery specimens obtained at autopsy. Subsequent work on imaging carotid arteries in vivo in patients referred for endarterectomy showed a high correlation with pathology and with previous ex vivo results.

A recent study in patients with plaques in the thoracic aorta showed that when compared to transesophageal echocardiography, plaque composition and size are accurately characterized and measured using in vivo MRI. Carotid and aortic athero-thrombotic plaque assessment by MRI may lend itself to use as a screening tool for prediction of future cardiovascular events and for the evaluation of therapeutic intervention benefits.

These MR techniques have been also adapted for the study of plaques in different animal models. Therefore, MRI can be used as an investigative to follow in vivo progression, regression and plaque stabilization in different transgenic and non-transgenic animal models.

The ultimate goal is imaging of plaque in vivo in human coronary arteries. Preliminary studies in a porcine model of athero-thrombosis showed that the major difficulties of MR coronary wall imaging are due to the combination of cardiac and respiratory motion artifacts, the non-linear course of the coronary arteries, as well as their relatively small size and location.

Studies in an in-vivo pig model and in humans suggest that MRI may soon be applicable to study and characterize athero-thrombotic plaques in human coronaries in vivo. We have shown recently the utility of MRI in the study of treatment in humans. MR was used to measure the effect of lipid-lowering therapy (statins) in asymptomatic untreated hypercholesterolemic patients with carotid and aortic atherosclerosis.

In conclusion, the assessment of athero-thrombotic plaques by imaging techniques is essential for the identification of vulnerable plaques. In vivo, high-resolution, multi-contrast, MRI holds the best promise of non-invasively imaging vulnerable plaques and characterizing the different components in all arteries including the coronary arteries. MR allows serial evaluation assessment of the progression and regression of atherosclerosis over time. The use of specific MR contrast agents targeted for athero-thrombotic plaque imaging may enhance the plaque characterization. Application of MRI opens new areas for diagnosis, prevention, and treatment (e.g., lipid-lowering drug regimens) of athero-thrombosis in all arterial locations.

Roberto Corti, MD
Cardiology, University Hospital Zurich
Switzerland

Important: This press release accompanies both a presentation and an ESC press conference given at the ESC Congress 2003. Written by the investigator himself/herself, this press release does not necessarily reflect the opinion of the European Society of Cardiology


Camilla Dormer | alfa
Further information:
http://www.escardio.org

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>