Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Comparison of efficacy of the implantable defibrillator in Europe and in the United States

01.09.2003


ESC Congress 2003



Sudden cardiac death from ventricular tachyarrhythmias is the leading cause of death in Europe and the US. It effects hundreds of thousands people each year. Many of them have known heart disease, mainly coronary artery disease. The implantable defibrillator (ICD) effectively treats such arrhythmias and prevents sudden cardiac death. Identification of patients at risk who may gain profit from prophylactic ICD implantation remains a difficult task for the cardiologist.

The Multicenter Automatic Defibrillator Implantation Trial II (MADIT II) enrolled patients with a history of myocardial infarction and severely depressed left ventricular function without a history of life-threatening arrhythmias. The study was supported by an unrestricted research grant from GUIDANT, St.Paul, Minn. Patients were randomized to receive best medical therapy only or ICD implantation on top of best therapy. Over the course of four years 1232 patients were enrolled from 71 centers in the US and 5 centers in Europe. After a mean follow-up of 20 months, ICD therapy was associated with a 31 percent reduction in the risk of death.


In order to assess potential differences in clinical characteristics and outcome between European and US patients enrolled in the MADIT II trial ICD efficacy in the European patients was compared with US patients. European centers enrolled 109 (9%) of the total 1232 patients. European patients were younger, had a higher prevalence of symptomatic heart failure, but had a higher left ventricular ejection fraction than US patients. The percentage of female patients enrolled in MADIT II was lower in Europe than in the US (8% vs. 16%). Patients in Europe received more single chamber ICDs than US patients (86% vs. 53%). Also medications for the treatment of heart failure were slightly different in European and US patients.

During the course of the study, appropriate ICD therapy was similar in both groups. There was no difference in the incidence of arrhythmic death, heart failure death and overall mortality between European and US patients.

Although some differences in patient characteristics exist between patients enrolled in MADIT II in Europe and the United States with different rates of implantation of single vs. dual chamber ICD units, ICD efficacy seems to be similar in the two geographic regions.

Dr. Sven Reek
Univ. Hospitals Magdeburg, Div. of Cardiology
Germany

Important: This press release accompanies a poster or oral session given at the ESC Congress 2003. Written by the investigator himself/herself, this press release does not necessarily reflect the opinion of the European Society of Cardiology

Camilla Dormer | alfa
Further information:
http://www.escardio.org

More articles from Health and Medicine:

nachricht Chances to treat childhood dementia
24.07.2017 | Julius-Maximilians-Universität Würzburg

nachricht World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

Ultrathin device harvests electricity from human motion

24.07.2017 | Power and Electrical Engineering

Scientists announce the quest for high-index materials

24.07.2017 | Materials Sciences

ADIR Project: Lasers Recover Valuable Materials

24.07.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>