Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Comparison of efficacy of the implantable defibrillator in Europe and in the United States

01.09.2003


ESC Congress 2003



Sudden cardiac death from ventricular tachyarrhythmias is the leading cause of death in Europe and the US. It effects hundreds of thousands people each year. Many of them have known heart disease, mainly coronary artery disease. The implantable defibrillator (ICD) effectively treats such arrhythmias and prevents sudden cardiac death. Identification of patients at risk who may gain profit from prophylactic ICD implantation remains a difficult task for the cardiologist.

The Multicenter Automatic Defibrillator Implantation Trial II (MADIT II) enrolled patients with a history of myocardial infarction and severely depressed left ventricular function without a history of life-threatening arrhythmias. The study was supported by an unrestricted research grant from GUIDANT, St.Paul, Minn. Patients were randomized to receive best medical therapy only or ICD implantation on top of best therapy. Over the course of four years 1232 patients were enrolled from 71 centers in the US and 5 centers in Europe. After a mean follow-up of 20 months, ICD therapy was associated with a 31 percent reduction in the risk of death.


In order to assess potential differences in clinical characteristics and outcome between European and US patients enrolled in the MADIT II trial ICD efficacy in the European patients was compared with US patients. European centers enrolled 109 (9%) of the total 1232 patients. European patients were younger, had a higher prevalence of symptomatic heart failure, but had a higher left ventricular ejection fraction than US patients. The percentage of female patients enrolled in MADIT II was lower in Europe than in the US (8% vs. 16%). Patients in Europe received more single chamber ICDs than US patients (86% vs. 53%). Also medications for the treatment of heart failure were slightly different in European and US patients.

During the course of the study, appropriate ICD therapy was similar in both groups. There was no difference in the incidence of arrhythmic death, heart failure death and overall mortality between European and US patients.

Although some differences in patient characteristics exist between patients enrolled in MADIT II in Europe and the United States with different rates of implantation of single vs. dual chamber ICD units, ICD efficacy seems to be similar in the two geographic regions.

Dr. Sven Reek
Univ. Hospitals Magdeburg, Div. of Cardiology
Germany

Important: This press release accompanies a poster or oral session given at the ESC Congress 2003. Written by the investigator himself/herself, this press release does not necessarily reflect the opinion of the European Society of Cardiology

Camilla Dormer | alfa
Further information:
http://www.escardio.org

More articles from Health and Medicine:

nachricht Second cause of hidden hearing loss identified
20.02.2017 | Michigan Medicine - University of Michigan

nachricht Prospect for more effective treatment of nerve pain
20.02.2017 | Universität Zürich

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Switched-on DNA

20.02.2017 | Materials Sciences

Second cause of hidden hearing loss identified

20.02.2017 | Health and Medicine

Prospect for more effective treatment of nerve pain

20.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>