Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Comparison of efficacy of the implantable defibrillator in Europe and in the United States

01.09.2003


ESC Congress 2003



Sudden cardiac death from ventricular tachyarrhythmias is the leading cause of death in Europe and the US. It effects hundreds of thousands people each year. Many of them have known heart disease, mainly coronary artery disease. The implantable defibrillator (ICD) effectively treats such arrhythmias and prevents sudden cardiac death. Identification of patients at risk who may gain profit from prophylactic ICD implantation remains a difficult task for the cardiologist.

The Multicenter Automatic Defibrillator Implantation Trial II (MADIT II) enrolled patients with a history of myocardial infarction and severely depressed left ventricular function without a history of life-threatening arrhythmias. The study was supported by an unrestricted research grant from GUIDANT, St.Paul, Minn. Patients were randomized to receive best medical therapy only or ICD implantation on top of best therapy. Over the course of four years 1232 patients were enrolled from 71 centers in the US and 5 centers in Europe. After a mean follow-up of 20 months, ICD therapy was associated with a 31 percent reduction in the risk of death.


In order to assess potential differences in clinical characteristics and outcome between European and US patients enrolled in the MADIT II trial ICD efficacy in the European patients was compared with US patients. European centers enrolled 109 (9%) of the total 1232 patients. European patients were younger, had a higher prevalence of symptomatic heart failure, but had a higher left ventricular ejection fraction than US patients. The percentage of female patients enrolled in MADIT II was lower in Europe than in the US (8% vs. 16%). Patients in Europe received more single chamber ICDs than US patients (86% vs. 53%). Also medications for the treatment of heart failure were slightly different in European and US patients.

During the course of the study, appropriate ICD therapy was similar in both groups. There was no difference in the incidence of arrhythmic death, heart failure death and overall mortality between European and US patients.

Although some differences in patient characteristics exist between patients enrolled in MADIT II in Europe and the United States with different rates of implantation of single vs. dual chamber ICD units, ICD efficacy seems to be similar in the two geographic regions.

Dr. Sven Reek
Univ. Hospitals Magdeburg, Div. of Cardiology
Germany

Important: This press release accompanies a poster or oral session given at the ESC Congress 2003. Written by the investigator himself/herself, this press release does not necessarily reflect the opinion of the European Society of Cardiology

Camilla Dormer | alfa
Further information:
http://www.escardio.org

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Strathclyde-led research develops world's highest gain high-power laser amplifier

The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.

The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

New insights into the ancestors of all complex life

29.05.2017 | Earth Sciences

New photocatalyst speeds up the conversion of carbon dioxide into chemical resources

29.05.2017 | Life Sciences

NASA's SDO sees partial eclipse in space

29.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>