Are they really capable of replacing injured cells and reducing infarct size?
The new concept of cell transplantation has been addressed by two recent human investigations. Bone marrow cells of the patient are injected into the coronary circulation about one week after myocardial infarct to replace the injured cells and reduce the infarct size. This intervention seemed to be successful to reduce the contractile malefunction after myocardial infarction. The background of this observation is the new concept derived from animal experiments that some of adult bone marrow cells can home in the heart and then transdifferentiate to myocardial cells. Therefore, our goal in the present investigation was to repeat these clinical investigations in patients with large anterior myocardial infarcts.
Once the patients came into the hospital with an acute myocardial infarct the occluded vessel was mechanically recanalized with a balloon catheter to restore the blood flow instantly and the occlusion area was protected with a coronary stent.
Although blood flow is then re-established – due to the interruption of blood flow for several hours – many cells are dying and a myocardial scar is developing. Therefore, after 7 days 30 ml of bone marrow was drawn from a puncture of a hip bone and a certain subset of the cells (monocytic cells) were separated to a final volume of a about 8 – 10 ml containing 2.2 x 107 monocytic bone marrow cells. By a second catheterisation these cells were transferred into the coronary circulation over a balloon catheter into the injured tissue. The regional contractile force, the global contractile force and the regional coronary blood flow was measured at 3 month and 1 year after cell injection.
Camilla Dormer | alfa
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