Are they really capable of replacing injured cells and reducing infarct size?
The new concept of cell transplantation has been addressed by two recent human investigations. Bone marrow cells of the patient are injected into the coronary circulation about one week after myocardial infarct to replace the injured cells and reduce the infarct size. This intervention seemed to be successful to reduce the contractile malefunction after myocardial infarction. The background of this observation is the new concept derived from animal experiments that some of adult bone marrow cells can home in the heart and then transdifferentiate to myocardial cells. Therefore, our goal in the present investigation was to repeat these clinical investigations in patients with large anterior myocardial infarcts.
Once the patients came into the hospital with an acute myocardial infarct the occluded vessel was mechanically recanalized with a balloon catheter to restore the blood flow instantly and the occlusion area was protected with a coronary stent.
Although blood flow is then re-established – due to the interruption of blood flow for several hours – many cells are dying and a myocardial scar is developing. Therefore, after 7 days 30 ml of bone marrow was drawn from a puncture of a hip bone and a certain subset of the cells (monocytic cells) were separated to a final volume of a about 8 – 10 ml containing 2.2 x 107 monocytic bone marrow cells. By a second catheterisation these cells were transferred into the coronary circulation over a balloon catheter into the injured tissue. The regional contractile force, the global contractile force and the regional coronary blood flow was measured at 3 month and 1 year after cell injection.
Camilla Dormer | alfa
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Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of light metals.
Scientists at the University of Stuttgart have now developed two new process variants that will considerably expand the areas of application for friction stir welding.
Technologie-Lizenz-Büro (TLB) GmbH supports the University of Stuttgart in patenting and marketing its innovations.
Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of...
Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.
Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...
The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.
“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...
With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.
Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...
For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.
Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...
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28.09.2016 | Event News
27.09.2016 | Event News
29.09.2016 | Materials Sciences
29.09.2016 | Materials Sciences
29.09.2016 | Interdisciplinary Research