Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

C-reactive protein, an inflammatory biomarker, predicts progression of aortic valve stenosis

01.09.2003


ESC Congress 2003



Aortic stenosis (AS) is the narrowing or obstruction of the heart´s aortic valve, which prevents it from opening properly and blocks the flow of blood from the left ventricle to the aorta. AS is common in the ageing population and has become the most frequent native valve disease in Europe. AS when severe, may cause left heart failure, fainting or angina, but the natural progression of less severe degrees is highly variable.

The risk factors for the development of AS are the same as that of atherosclerosis (male sex, smoking, hypertension, age, hypercholesterolemia, and diabetes), and some of these seem to have an effect on AS progression as well. Numerous studies have identified inflammation as a major component of atherosclerosis complications and have shown that blood levels of C-reactive protein are elevated many years before a first heart attack or stroke occurs. C-reactive protein is a protein in the body whose level increases when blood vessels become inflamed, so measuring cardiovascular risk is thought to be possible by assessing C-reactive protein levels.


Accordingly, to these data, we have studied the possible association between inflammation, as detected by C-reactive protein levels, and progression of AS.

Our study was carried out in Salamanca, Spain. We looked at 43 patients with AS. We performed an echocardiogram and measured the blood levels of C-reactive protein at the beginning of the study, and we saw that patients with higher levels of C-reactive protein had more rapid progression of AS than patients with lower levels, when we repeat the echocardiogram six months later.

The mechanism of this is still under investigation, but raises the possibility that AS and atherosclerosis may share common pathophysiology pathways. Ability to predict AS progression has clinical implications in patients with AS, and could help in the selection of patients who are likely to benefit from early aortic valve replacement.

Pedro L Sanchez
University Hospital, Salamanca, Spain

IMPORTANT: This press release accompanies a poster or oral session given at the ESC Congress 2003. Written by the investigator himself/herself, this press release does not necessarily reflect the opinion of the European Society of Cardiology

Camilla Dormer | alfa
Further information:
http://www.escardio.org/vpo

More articles from Health and Medicine:

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

nachricht Flexible sensors can detect movement in GI tract
11.10.2017 | Massachusetts Institute of Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Ocean atmosphere rife with microbes

17.10.2017 | Life Sciences

Neutrons observe vitamin B6-dependent enzyme activity useful for drug development

17.10.2017 | Life Sciences

NASA finds newly formed tropical storm lan over open waters

17.10.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>