The most important antibiotics in general use today are the b-lactam family of products, but the medical community faces a serious problem with these antibiotics: the increasing development of drug resistance. The resistance is caused by hydrolysis of the b-lactam by a bacterial lactamase enzyme, but fortunately it can often be overcome by the use of a serine b-lactamase inhibitor in combination with the drug. This approach is successfully used already, for example clavulanic acid is used in combination with amoxycillin in Augmentin.
Unfortunately, various b-lactam drugs are also inactivated by metallo-b-lactamases, which cannot be overcome by the current range of serine b-lactamase inhibitors. Until recently, there have been no metallo-b-lactamase inhibitors of any kind to protect the drugs from this type of resistance.
Researchers at Oxford University’s Department of Chemistry now believe they have found a solution to this problem. They have discovered a new class of inhibitors of Class B bacterial lactamases, which are responsible for the hydrolysis of many antibiotics and hence drug resistance in those bacteria.
Jennifer Johnson | alfa
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The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
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With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
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Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
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