In the future, many cancer scientists and physicians believe, a "molecular fingerprint" of an individual´s cancer may be used to diagnose that patient´s disease and tailor therapy.
Researchers at Vanderbilt have moved a step closer to that scenario with the identification of a distinct pattern of expression of 15 proteins in lung cancers that can predict a poor prognosis or a good prognosis. All patients in the poor prognosis group had died one year after diagnosis, while all patients in the good prognosis group were still alive. Median survival, the point at which half the patients were still alive, was six months for the poor prognosis group, compared to 33 months for the good prognosis group. "If this pattern is confirmed in larger studies, its prognostic power exceeds that of virtually any previously published standard molecular marker," the authors write in the August 9 issue of The Lancet.
The scientists also demonstrate that protein profiles obtained from a tiny amount of tumor tissue – only 1 millimeter in diameter and only 1/1000 of a millimeter in thickness - can be used to predict risk that the cancer has spread to nearby lymph nodes.
Predictions based on protein profiles were confirmed by pathological evaluation under a microscope. In one case, a large cell carcinoma may have been misclassified based on protein patterns as an adenocarcinoma, but the investigators report that this tumor may actually be an adenocarcinoma that is too poorly differentiated to identify as such under the microscope.
The investigators note that using protein profiles to make distinctions that are already apparent under the microscope offers little use in clinical care, although the approach is potentially useful in identifying novel therapeutic targets. However, the ability to use protein profiles to predict node involvement or to identify patients as high- or low-risk could have great implications for treatment strategies, Carbone said.
"Because such small tissue samples are needed, it would be of great interest to analyze protein expression patterns of tissue samples from needle aspirations or from different cell subtypes within the lung," Carbone said. "It also would be interesting to look for patterns associated with response to specific therapies, with smoking exposure, or with preneoplasia and the progression to cancer.
"If these data are confirmed using larger numbers of patients, this technology could have significant implications for the clinical management of non-small cell lung cancer."
Contact: Cynthia Floyd Manley, firstname.lastname@example.org
Cynthia Floyd Manley | EurekAlert!
Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences
What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy