Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Collagen based wound sealant

28.07.2003



A collagen-based wound sealant recently developed at Texas A&M University could be an alternative for human and animal wound care treatment.

The material – which can be poured or injected into the wound – speeds the closure of wounds, said Dr. Douglas Miller, research scientist with the Texas Agricultural Experiment Station and one of the scientists working on the project.

In testing, Miller and his colleagues found a significant difference in closure between treated and untreated wounds in laboratory rats. The treated wounds had the same amount of healing in three days as the controls in six days, thus speeding the closure of the wound by about 50 percent.



In other words, "The size of the wound shrank more rapidly when treated with the sealant," he said.

Normally minor soft tissue wounds can repair themselves with minimal treatment, he said. However, diabetic ulcers or sores that heal slowly are another story.

Over human history, thousands of preparations and treatments have been developed to assist in wound repair, he explained. Collagen itself has long been considered a favorite material for wound treatment because it is inexpensive, easily prepared and can be readily shaped to fit the wound site, Miller said. As a natural part of the body, it also causes few allergic reactions.

"Collagen is the most abundant protein in the mammalian body, and in skin, it’s about 60 percent of your total protein," he said.

"It’s been described as literally the glue that holds you together. The bottom line is that collagen has been used for centuries as something to repair wounds because it is a natural component of the tissue."

But collagen treatments alone "don’t bind the wound," Miller said.

Miller and the other researchers developed a matrix – or mixture – of collagen and other ingredients, as well as a polymerization (chemical) process that helps bind the sealant to the wound. The material, in texture, resembles gelatin but is flexible. Gelatin, on the other hand, is brittle and tears easily.

"If you’ve got a large, open wound, your body moves, your skin moves, your muscles flex, and if this doesn’t flex with it, it simply is going to tear. This has good mechanical strength, but it also has elasticity," he said.

Miller estimated the collagen-based sealant needs to be applied only once, therefore making it relatively inexpensive compared to other treatments.

About 10 ml – enough to fill a wound a little more than 1 inch in diameter and ½ inch deep – could be made for less than $100, he said. Even if a production as a medical grade material increases the cost, it still would be cheaper than repeated visits to the physician’s office to keep getting the wound cleaned, treated and re-bandaged several times a week, Miller said.

"One dose of this could replace all of that, and all you have to do is change the covering a couple of times a week," he said.

Miller also believes other healing promoters – such as slow-release antibiotics – could be added to the sealant. Basic Fibroblast growth factor, a protein which stimulates the growth of new connective tissue and blood vessels, already has been tested and found to further increase the rate of wound closure in 1-year-old rats.

He hopes further animal and human studies can begin soon.

"We cannot claim it increases the incidence of healing. That has not been tested yet. We observed that it seems to have decreased the visibility of scars, but we didn’t test that either."

Additional uses for this material might include a slow release depot for vaccines, adjuvants or drugs; bone repair; or graft or prosthetic implant stabilization.

"This product would have a potential widespread market throughout veterinary medical, and human medical and dental practice," he said.

Edith A. Chenault | Texas A&M University
Further information:
http://www.tamu.edu

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>