In an article appearing in a special issue of the Journal of Neuro-oncology, researchers at Cedars-Sinai Medical Centers Maxine Dunitz Neurosurgical Institute describe a complex cell-level process that allows malignant brain tumors to protect themselves by damaging the thymus, rapidly degrading the immune system. In a second article, Institute scientists identify a molecular mechanism that causes cell death of cancer-fighting lymphocytes as they infiltrate a brain tumor.
"We are dissecting and better understanding the mechanisms that enable tumors to evade destruction by the immune system. This gives us new tools in our fight against brain cancer, to essentially correct these deficits and further enhance the ability of the immune system, not only to detect but also to destroy brain tumors," said Keith L. Black, M.D., director of the Institute, Cedars-Sinais Division of Neurosurgery and the Comprehensive Brain Tumor Program.
In an animal study, researchers found that intracranial gliomas – aggressive brain tumors – damage the thymus, the gland responsible for the development and potency of the immune systems T cells. As the thymus shrinks and its normal structure becomes distorted, many of the thymocytes – the "immature" cells destined to become functional T cells potentially capable of destroying a variety of antigens – undergo a process that weakens and kills them.
Sandra Van | EurekAlert!
Improving memory with magnets
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Graphene-based neural probes probe brain activity in high resolution
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The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
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