In an article appearing in a special issue of the Journal of Neuro-oncology, researchers at Cedars-Sinai Medical Centers Maxine Dunitz Neurosurgical Institute describe a complex cell-level process that allows malignant brain tumors to protect themselves by damaging the thymus, rapidly degrading the immune system. In a second article, Institute scientists identify a molecular mechanism that causes cell death of cancer-fighting lymphocytes as they infiltrate a brain tumor.
"We are dissecting and better understanding the mechanisms that enable tumors to evade destruction by the immune system. This gives us new tools in our fight against brain cancer, to essentially correct these deficits and further enhance the ability of the immune system, not only to detect but also to destroy brain tumors," said Keith L. Black, M.D., director of the Institute, Cedars-Sinais Division of Neurosurgery and the Comprehensive Brain Tumor Program.
In an animal study, researchers found that intracranial gliomas – aggressive brain tumors – damage the thymus, the gland responsible for the development and potency of the immune systems T cells. As the thymus shrinks and its normal structure becomes distorted, many of the thymocytes – the "immature" cells destined to become functional T cells potentially capable of destroying a variety of antigens – undergo a process that weakens and kills them.
Sandra Van | EurekAlert!
Staphylococcus aureus: A new mechanism involved in virulence and antibiotic resistance
23.03.2018 | Institut Pasteur
Scientists develop tiny tooth-mounted sensors that can track what you eat
22.03.2018 | Tufts University
Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.
The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
23.03.2018 | Event News
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23.03.2018 | Physics and Astronomy