Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New protein may play a role in obesity

24.07.2003


There is more to losing weight than diet and exercise, according to investigators the Research Institute at the McGill University Health Centre (MUHC). Their study is the first to identify a new receptor protein present on fat cells that may play a role in fat metabolism. The findings, published recently in the Journal of Biological Chemistry, have implications for the many individuals suffering from obesity.



"We have identified a receptor protein on fat cells that when stimulated may increase the amount of lipid stored in fat reservoirs," says MUHC researcher Dr. Katherine Cianflone. "This protein, C5L2, is made by fat tissue, is on the surface of fat cells and binds a specific hormone to increase fat production."

Cianflone, an Associate Professor at McGill University, with colleagues from McGill University and the United Kingdom characterized the binding activities of C5L2. They showed that this protein is a cell surface receptor that binds acylation stimulating protein (ASP), a protein known to affect fat production.


"People who are obese have high levels of ASP," says Cianflone. "One potential key to battling this condition is to disrupt the ASP-C5L2 complex. In the future, we may be able to slow down this fat-producing process by identifying molecules that will block C5L2 activity."

In North America obesity is at epidemic levels in all age groups. A large proportion of Canadians is overweight or obese, and is at risk for heart disease, diabetes, and cardiovascular problems. "The most powerful method to reduce these risks is to reduce their weight," says Cianflone.

"By providing funding for researchers like Dr. Cianflone and her colleagues, CIHR is helping us better understand one of many complex pathways involved in regulating body weight," says Dr. Diane Finegood, Scientific Director of the CIHR Institute of Nutrition, Metabolism and Diabetes which has identified obesity research as its strategic funding priority. "We need to know much more about human biology, as well as human behaviour, if we are to come to grips with the obesity epidemic and its many adverse consequences affecting the health of Canadians."

"The Heart and Stroke Foundation of Québec (HSFQ) recognizes the danger that obesity represents for cardiovascular diseases. It is thus essential for us to financially support research which will make it possible to fight this plague and thus improve the quality of life of the population ", mentioned the general manager of the HSFQ, Mr. Jean Noël.

Christine Zeindler | EurekAlert!
Further information:
http://www.mcgill.ca

More articles from Health and Medicine:

nachricht Nanoparticles as a Solution against Antibiotic Resistance?
15.12.2017 | Friedrich-Schiller-Universität Jena

nachricht Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

New technique could make captured carbon more valuable

15.12.2017 | Life Sciences

First-of-its-kind chemical oscillator offers new level of molecular control

15.12.2017 | Life Sciences

A chip for environmental and health monitoring

15.12.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>