Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New protein may play a role in obesity

24.07.2003


There is more to losing weight than diet and exercise, according to investigators the Research Institute at the McGill University Health Centre (MUHC). Their study is the first to identify a new receptor protein present on fat cells that may play a role in fat metabolism. The findings, published recently in the Journal of Biological Chemistry, have implications for the many individuals suffering from obesity.



"We have identified a receptor protein on fat cells that when stimulated may increase the amount of lipid stored in fat reservoirs," says MUHC researcher Dr. Katherine Cianflone. "This protein, C5L2, is made by fat tissue, is on the surface of fat cells and binds a specific hormone to increase fat production."

Cianflone, an Associate Professor at McGill University, with colleagues from McGill University and the United Kingdom characterized the binding activities of C5L2. They showed that this protein is a cell surface receptor that binds acylation stimulating protein (ASP), a protein known to affect fat production.


"People who are obese have high levels of ASP," says Cianflone. "One potential key to battling this condition is to disrupt the ASP-C5L2 complex. In the future, we may be able to slow down this fat-producing process by identifying molecules that will block C5L2 activity."

In North America obesity is at epidemic levels in all age groups. A large proportion of Canadians is overweight or obese, and is at risk for heart disease, diabetes, and cardiovascular problems. "The most powerful method to reduce these risks is to reduce their weight," says Cianflone.

"By providing funding for researchers like Dr. Cianflone and her colleagues, CIHR is helping us better understand one of many complex pathways involved in regulating body weight," says Dr. Diane Finegood, Scientific Director of the CIHR Institute of Nutrition, Metabolism and Diabetes which has identified obesity research as its strategic funding priority. "We need to know much more about human biology, as well as human behaviour, if we are to come to grips with the obesity epidemic and its many adverse consequences affecting the health of Canadians."

"The Heart and Stroke Foundation of Québec (HSFQ) recognizes the danger that obesity represents for cardiovascular diseases. It is thus essential for us to financially support research which will make it possible to fight this plague and thus improve the quality of life of the population ", mentioned the general manager of the HSFQ, Mr. Jean Noël.

Christine Zeindler | EurekAlert!
Further information:
http://www.mcgill.ca

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>