Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New protein may play a role in obesity

24.07.2003


There is more to losing weight than diet and exercise, according to investigators the Research Institute at the McGill University Health Centre (MUHC). Their study is the first to identify a new receptor protein present on fat cells that may play a role in fat metabolism. The findings, published recently in the Journal of Biological Chemistry, have implications for the many individuals suffering from obesity.



"We have identified a receptor protein on fat cells that when stimulated may increase the amount of lipid stored in fat reservoirs," says MUHC researcher Dr. Katherine Cianflone. "This protein, C5L2, is made by fat tissue, is on the surface of fat cells and binds a specific hormone to increase fat production."

Cianflone, an Associate Professor at McGill University, with colleagues from McGill University and the United Kingdom characterized the binding activities of C5L2. They showed that this protein is a cell surface receptor that binds acylation stimulating protein (ASP), a protein known to affect fat production.


"People who are obese have high levels of ASP," says Cianflone. "One potential key to battling this condition is to disrupt the ASP-C5L2 complex. In the future, we may be able to slow down this fat-producing process by identifying molecules that will block C5L2 activity."

In North America obesity is at epidemic levels in all age groups. A large proportion of Canadians is overweight or obese, and is at risk for heart disease, diabetes, and cardiovascular problems. "The most powerful method to reduce these risks is to reduce their weight," says Cianflone.

"By providing funding for researchers like Dr. Cianflone and her colleagues, CIHR is helping us better understand one of many complex pathways involved in regulating body weight," says Dr. Diane Finegood, Scientific Director of the CIHR Institute of Nutrition, Metabolism and Diabetes which has identified obesity research as its strategic funding priority. "We need to know much more about human biology, as well as human behaviour, if we are to come to grips with the obesity epidemic and its many adverse consequences affecting the health of Canadians."

"The Heart and Stroke Foundation of Québec (HSFQ) recognizes the danger that obesity represents for cardiovascular diseases. It is thus essential for us to financially support research which will make it possible to fight this plague and thus improve the quality of life of the population ", mentioned the general manager of the HSFQ, Mr. Jean Noël.

Christine Zeindler | EurekAlert!
Further information:
http://www.mcgill.ca

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>