Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Early heart disease in parents linked to thicker artery walls in offspring

23.07.2003


If your parents had coronary heart disease before age 60, the walls of your neck arteries are more likely to be thicker, putting you at higher risk of heart disease, too, researchers report in today´s rapid access issue of Circulation: Journal of the American Heart Association.



Compared with people with no parental history of early-onset coronary heart disease (CHD), those with at least one parent who had a heart attack or other coronary event such as chest pain before age 60, had thicker walls in the large carotid arteries of the neck that lead to the brain, researchers found. Thicker carotid artery walls are associated with a greater degree of atherosclerotic plaque.

The study investigated the symptomless thickening of carotid arteries called subclinical atherosclerosis.


"Studies have shown that subclinical atherosclerosis, as assessed by increased thickness of the carotid artery wall, is directly predictive of an increased risk of heart attack or stroke," says principal investigator Christopher J. O´Donnell, M.D., M.P.H., associate director of the National Heart, Lung, and Blood Institute´s Framingham Heart Study.

The investigators studied a subset of men and women enrolled in the Framingham Offspring Study, a study of 5,124 offspring (and their spouses) of the original participants in the Framingham Heart Study. In this analysis, the researchers studied 1,662 men and women, average age 57, whose biological parents were both in the original Framingham study. Between 1995 and 1998, the offspring underwent carotid ultrasound imaging to measure their carotid walls. This noninvasive imaging technique detects vascular disease before symptoms are present.

O´Donnell notes that many previous studies investigating family history relied on the offspring´s reports to determine if parents had heart disease. This introduces the possibility of recall bias, as people with a personal history of heart disease may be more cognizant of their parents´ cardiovascular history, he explains. In the Framingham studies, researchers collected information about heart disease in a prospective fashion, with both the parents and children undergoing examinations every few years – the parents since 1948, the offspring since 1971.

The study showed that at any age, the average vessel wall thickness of the internal carotid arteries was greater in people with at least one parent who developed CHD before age 60, compared with those without a parental history of early-onset CHD.

"The association holds true for both men and women and is significant even after adjustment for other strong risk factors for atherosclerosis such as high blood pressure and high cholesterol," adds Thomas J. Wang, M.D. a Framingham Heart Study researcher and the study´s lead author.

In men, the average thickness, after adjustment, was 1.12 millimeters (mm) in the group in which at least one parent developed premature CHD, compared with 1.05 mm in the group in which neither parent had premature CHD. In women, the values were 0.92 mm for those with a parental history of premature CHD and 0.85 mm for those without it.

"The findings add to multiple studies recognizing that parental history of coronary heart disease is a risk factor for clinical disease and should be taken seriously," Wang says. "These data support guidelines saying that more rigorous preventive measures should be undertaken if an individual has a family history of heart disease."

"The fact that the association between artery wall thickness and premature parental coronary heart disease remains significant even after adjustment for traditional risk factors suggests that there are genetic causes to subclinical atherosclerosis that go beyond traditional risk factors," he says. "Our logical next step is to identify the mechanisms - including specific genes - underlying this connection between the familial clustering of early-onset heart disease and increased vessel wall thickness. The goal is to find new and effective ways to predict and prevent heart disease and stroke at an early age."

Carole Bullock | EurekAlert!
Further information:
http://www.americanheart.org

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>