Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Early heart disease in parents linked to thicker artery walls in offspring

23.07.2003


If your parents had coronary heart disease before age 60, the walls of your neck arteries are more likely to be thicker, putting you at higher risk of heart disease, too, researchers report in today´s rapid access issue of Circulation: Journal of the American Heart Association.



Compared with people with no parental history of early-onset coronary heart disease (CHD), those with at least one parent who had a heart attack or other coronary event such as chest pain before age 60, had thicker walls in the large carotid arteries of the neck that lead to the brain, researchers found. Thicker carotid artery walls are associated with a greater degree of atherosclerotic plaque.

The study investigated the symptomless thickening of carotid arteries called subclinical atherosclerosis.


"Studies have shown that subclinical atherosclerosis, as assessed by increased thickness of the carotid artery wall, is directly predictive of an increased risk of heart attack or stroke," says principal investigator Christopher J. O´Donnell, M.D., M.P.H., associate director of the National Heart, Lung, and Blood Institute´s Framingham Heart Study.

The investigators studied a subset of men and women enrolled in the Framingham Offspring Study, a study of 5,124 offspring (and their spouses) of the original participants in the Framingham Heart Study. In this analysis, the researchers studied 1,662 men and women, average age 57, whose biological parents were both in the original Framingham study. Between 1995 and 1998, the offspring underwent carotid ultrasound imaging to measure their carotid walls. This noninvasive imaging technique detects vascular disease before symptoms are present.

O´Donnell notes that many previous studies investigating family history relied on the offspring´s reports to determine if parents had heart disease. This introduces the possibility of recall bias, as people with a personal history of heart disease may be more cognizant of their parents´ cardiovascular history, he explains. In the Framingham studies, researchers collected information about heart disease in a prospective fashion, with both the parents and children undergoing examinations every few years – the parents since 1948, the offspring since 1971.

The study showed that at any age, the average vessel wall thickness of the internal carotid arteries was greater in people with at least one parent who developed CHD before age 60, compared with those without a parental history of early-onset CHD.

"The association holds true for both men and women and is significant even after adjustment for other strong risk factors for atherosclerosis such as high blood pressure and high cholesterol," adds Thomas J. Wang, M.D. a Framingham Heart Study researcher and the study´s lead author.

In men, the average thickness, after adjustment, was 1.12 millimeters (mm) in the group in which at least one parent developed premature CHD, compared with 1.05 mm in the group in which neither parent had premature CHD. In women, the values were 0.92 mm for those with a parental history of premature CHD and 0.85 mm for those without it.

"The findings add to multiple studies recognizing that parental history of coronary heart disease is a risk factor for clinical disease and should be taken seriously," Wang says. "These data support guidelines saying that more rigorous preventive measures should be undertaken if an individual has a family history of heart disease."

"The fact that the association between artery wall thickness and premature parental coronary heart disease remains significant even after adjustment for traditional risk factors suggests that there are genetic causes to subclinical atherosclerosis that go beyond traditional risk factors," he says. "Our logical next step is to identify the mechanisms - including specific genes - underlying this connection between the familial clustering of early-onset heart disease and increased vessel wall thickness. The goal is to find new and effective ways to predict and prevent heart disease and stroke at an early age."

Carole Bullock | EurekAlert!
Further information:
http://www.americanheart.org

More articles from Health and Medicine:

nachricht Nanoparticles as a Solution against Antibiotic Resistance?
15.12.2017 | Friedrich-Schiller-Universität Jena

nachricht Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>