Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

HepCgen genotyping service helps fight Hepatitis C, a "silent epidemic"

22.07.2003


Genotyping provides route to tailored treatment at lower cost with less side effects

A new centralised genotyping service that enables clinicians to differentiate between types of hepatitis C infections is poised to improve treatment for patients with Hepatitis C, a severely under treated viral infection in the UK. The new service, available through HepCgen will allow clinicians to tailor costly interferon-based treatment regimes to the patients’ viral genotype, thus lowering costs and side effects.

Although five times more prevalent than HIV, most cases of Hepatitis C go undetected, prompting the phrase ‘the silent epidemic’, therefore it is important that, once identified, diagnosis and treatment commence without delay. “HepCgen’s centralised Hepatitis C genotyping service allows hospitals throughout the UK extremely rapid access to this important information, without the need for an expensive and time consuming in-house genotyping set up”, said Paul Colford, CEO of HepCgen.



Through early identification of patients with genotype 1, or non-1, HepCgen is able to distinguish patients that may require lower doses for shorter periods of time. This knowledge not only has obvious benefits to the patient by reducing medication and associated side effects, but also provides a significant cost saving to healthcare funders: HepCgen founder Dr William Rosenberg estimates a saving to the NHS of half a billion pounds a year if doctors routinely use this service.

HepCgen regards cost of treatment as a significant factor in the number of patients undergoing treatment for Hepatitis C and Dr Rosenberg notes, “Of the 400,000 cases in the UK only about 20,000-30,000 are in secondary care and of those, only some 2,000 cases are being treated, because the NHS won’t release funding for treatment.”

Further evidence of the importance placed on genotyping in the treatment of hepatitis C came with Roche’s announcement on 18th July of the European Commission’s approval of a new label for PEGASYS, Roche’s flagship treatment for the hepatitis C virus. The approval came as a result of a pivotal study by Roche, demonstrating that the duration of combination therapy and dose of Copegus (ribavirin) for chronic hepatitis C patients depends on viral genotype. Dr. Rosenberg continues, “We have demonstrated similar data with the Schering-Plough therapy, among others. The importance of identifying genotype in the treatment of Hepatitis C is becoming rapidly accepted. This recognition by the European Commission is strong additional testimony.”

“HepCgen currently provides its proprietary services to over 20 centres in the UK, most of which are reimbursed by the major pharmaceutical companies involved in Hepatitis C”, stated Mr Colford. “We would like to expand our services throughout Europe, as countries like Italy, Germany, and France are treating over five times the number of patients the UK chooses to, and will tremendously benefit by either using HepCgen services or licensing this technology. ”

HepCgen Ltd was recently spun out of the University of Southampton and specialises in diagnostics and treatments for chronic liver disease. Dr. Spike Willcocks, IP2IPO adds, “HepCgen is a very exciting opportunity in our portfolio, whose technology meets a now widely recognised medical need, and this step demonstrates the increasing value of the Company. Further development in this area could be rapidly accelerated with additional financing in the near future.”

For more information, please contact:

At the company

Paul Colford, CEO HepCgen Ltd, paul.colford@hepcgen.com
Dr William Rosenberg, wmr@soton.ac.uk

Media enquiries

Dr. Spike Willcocks, IP2IPO, spike.wilcocks@ip2ipo.com
Sue Charles, Northbank Communications, s.charles@northbankcommunications.com
James Parkinson, Northbank Communications, j.parkinson@northbankcommunications.com

Louise Johnson | alfa
Further information:
http://www.hepcgen.com

More articles from Health and Medicine:

nachricht GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University

nachricht Scientists re-create brain neurons to study obesity and personalize treatment
20.04.2018 | Cedars-Sinai Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: BAM@Hannover Messe: innovative 3D printing method for space flight

At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.

Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Quantum Technology for Advanced Imaging – QUILT

24.04.2018 | Information Technology

AWI researchers measure a record concentration of microplastic in arctic sea ice

24.04.2018 | Earth Sciences

Complete skin regeneration system of fish unraveled

24.04.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>