Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

HepCgen genotyping service helps fight Hepatitis C, a "silent epidemic"

22.07.2003


Genotyping provides route to tailored treatment at lower cost with less side effects

A new centralised genotyping service that enables clinicians to differentiate between types of hepatitis C infections is poised to improve treatment for patients with Hepatitis C, a severely under treated viral infection in the UK. The new service, available through HepCgen will allow clinicians to tailor costly interferon-based treatment regimes to the patients’ viral genotype, thus lowering costs and side effects.

Although five times more prevalent than HIV, most cases of Hepatitis C go undetected, prompting the phrase ‘the silent epidemic’, therefore it is important that, once identified, diagnosis and treatment commence without delay. “HepCgen’s centralised Hepatitis C genotyping service allows hospitals throughout the UK extremely rapid access to this important information, without the need for an expensive and time consuming in-house genotyping set up”, said Paul Colford, CEO of HepCgen.



Through early identification of patients with genotype 1, or non-1, HepCgen is able to distinguish patients that may require lower doses for shorter periods of time. This knowledge not only has obvious benefits to the patient by reducing medication and associated side effects, but also provides a significant cost saving to healthcare funders: HepCgen founder Dr William Rosenberg estimates a saving to the NHS of half a billion pounds a year if doctors routinely use this service.

HepCgen regards cost of treatment as a significant factor in the number of patients undergoing treatment for Hepatitis C and Dr Rosenberg notes, “Of the 400,000 cases in the UK only about 20,000-30,000 are in secondary care and of those, only some 2,000 cases are being treated, because the NHS won’t release funding for treatment.”

Further evidence of the importance placed on genotyping in the treatment of hepatitis C came with Roche’s announcement on 18th July of the European Commission’s approval of a new label for PEGASYS, Roche’s flagship treatment for the hepatitis C virus. The approval came as a result of a pivotal study by Roche, demonstrating that the duration of combination therapy and dose of Copegus (ribavirin) for chronic hepatitis C patients depends on viral genotype. Dr. Rosenberg continues, “We have demonstrated similar data with the Schering-Plough therapy, among others. The importance of identifying genotype in the treatment of Hepatitis C is becoming rapidly accepted. This recognition by the European Commission is strong additional testimony.”

“HepCgen currently provides its proprietary services to over 20 centres in the UK, most of which are reimbursed by the major pharmaceutical companies involved in Hepatitis C”, stated Mr Colford. “We would like to expand our services throughout Europe, as countries like Italy, Germany, and France are treating over five times the number of patients the UK chooses to, and will tremendously benefit by either using HepCgen services or licensing this technology. ”

HepCgen Ltd was recently spun out of the University of Southampton and specialises in diagnostics and treatments for chronic liver disease. Dr. Spike Willcocks, IP2IPO adds, “HepCgen is a very exciting opportunity in our portfolio, whose technology meets a now widely recognised medical need, and this step demonstrates the increasing value of the Company. Further development in this area could be rapidly accelerated with additional financing in the near future.”

For more information, please contact:

At the company

Paul Colford, CEO HepCgen Ltd, paul.colford@hepcgen.com
Dr William Rosenberg, wmr@soton.ac.uk

Media enquiries

Dr. Spike Willcocks, IP2IPO, spike.wilcocks@ip2ipo.com
Sue Charles, Northbank Communications, s.charles@northbankcommunications.com
James Parkinson, Northbank Communications, j.parkinson@northbankcommunications.com

Louise Johnson | alfa
Further information:
http://www.hepcgen.com

More articles from Health and Medicine:

nachricht Electrical 'switch' in brain's capillary network monitors activity and controls blood flow
27.03.2017 | Larner College of Medicine at the University of Vermont

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Northern oceans pumped CO2 into the atmosphere

27.03.2017 | Earth Sciences

Fingerprint' technique spots frog populations at risk from pollution

27.03.2017 | Life Sciences

Big data approach to predict protein structure

27.03.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>