Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Canadian-led study identifies which colon cancer patients benefit from chemotherapy

17.07.2003


New insight is important step forward in personalized cancer care

A new Canadian-led study in the latest issue of the New England Journal of Medicine shows that a simple genetic test can determine if chemotherapy will be effective in treating a patient’s colon cancer, the second leading cause of cancer deaths in North America.
The study, led by doctors and researchers from Toronto’s Princess Margaret Hospital and Mount Sinai Hospital, examined 570 tissue samples from colon cancer patients. Colon cancer, which will kill an estimated 8,300 Canadians this year, is usually treated by a combination of surgery and chemotherapy.


The study determined that patients with a specific mutation in their tumor, called high-frequency microsatellite instability, did not benefit from chemotherapy, which can be a very difficult treatment with significant unpleasant side effects. The study’s findings represent a significant step forward in providing individualized treatment plans for colon cancer patients.

"This study shows that the usual type of chemotherapy is effective for about 83 per cent of colon cancer patients," said lead author Dr. Steven Gallinger, a surgical oncologist at Mount Sinai Hospital and University Health Network, as well as Professor of Surgery at University of Toronto. "Yet, for nearly 17 per cent of colon cancer patients, the traditional chemotherapy treatment is not helpful, and may even be harmful."

The study, which also involved doctors and researchers from the United States and France, shows that further investigation is needed to provide alternatives for these patients, such as new drugs that are effective on tumors with high-frequency microsatellite instability.

Testing for this genetic mutation could easily become a regular routine during diagnosis, with the results being used to direct the rational use of chemotherapy in colon cancer.

"Undergoing chemotherapy is not an easy decision. Side effects can include sore throat and mouth, tiredness, increased risk of infection, and in a small number of cases, even serious life-threatening illness," said Dr. Malcolm Moore, a Princess Margaret Hospital medical oncologist involved in the study. "If we can select the patients most likely to benefit from therapy, we can restrict therapy to that population and spare the remaining patients the trauma of that type of treatment."

Vince Rice | EurekAlert!
Further information:
http://www.utoronto.ca

More articles from Health and Medicine:

nachricht Custom-tailored strategy against glioblastomas
26.09.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New leukemia treatment offers hope
23.09.2016 | King Abdullah University of Science and Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

Im Focus: Complex hardmetal tools out of the 3D printer

For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.

Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...

Im Focus: Launch of New Industry Working Group for Process Control in Laser Material Processing

At AKL’16, the International Laser Technology Congress held in May this year, interest in the topic of process control was greater than expected. Appropriately, the event was also used to launch the Industry Working Group for Process Control in Laser Material Processing. The group provides a forum for representatives from industry and research to initiate pre-competitive projects and discuss issues such as standards, potential cost savings and feasibility.

In the age of industry 4.0, laser technology is firmly established within manufacturing. A wide variety of laser techniques – from USP ablation and additive...

Im Focus: New laser joining technologies at ‘K 2016’ trade fair

Every three years, the plastics industry gathers at K, the international trade fair for plastics and rubber in Düsseldorf. The Fraunhofer Institute for Laser Technology ILT will also be attending again and presenting many innovative technologies, such as for joining plastics and metals using ultrashort pulse lasers. From October 19 to 26, you can find the Fraunhofer ILT at the joint Fraunhofer booth SC01 in Hall 7.

K is the world’s largest trade fair for the plastics and rubber industry. As in previous years, the organizers are expecting 3,000 exhibitors and more than...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Experts from industry and academia discuss the future mobile telecommunications standard 5G

23.09.2016 | Event News

ICPE in Graz for the seventh time

20.09.2016 | Event News

Using mathematical models to understand our brain

16.09.2016 | Event News

 
Latest News

Stronger turbine blades with molybdenum silicides

26.09.2016 | Materials Sciences

Scientists Find Twisting 3-D Raceway for Electrons in Nanoscale Crystal Slices

26.09.2016 | Materials Sciences

Lowering the Heat Makes New Materials Possible While Saving Energy

26.09.2016 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>