Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Canadian-led study identifies which colon cancer patients benefit from chemotherapy

17.07.2003


New insight is important step forward in personalized cancer care

A new Canadian-led study in the latest issue of the New England Journal of Medicine shows that a simple genetic test can determine if chemotherapy will be effective in treating a patient’s colon cancer, the second leading cause of cancer deaths in North America.
The study, led by doctors and researchers from Toronto’s Princess Margaret Hospital and Mount Sinai Hospital, examined 570 tissue samples from colon cancer patients. Colon cancer, which will kill an estimated 8,300 Canadians this year, is usually treated by a combination of surgery and chemotherapy.


The study determined that patients with a specific mutation in their tumor, called high-frequency microsatellite instability, did not benefit from chemotherapy, which can be a very difficult treatment with significant unpleasant side effects. The study’s findings represent a significant step forward in providing individualized treatment plans for colon cancer patients.

"This study shows that the usual type of chemotherapy is effective for about 83 per cent of colon cancer patients," said lead author Dr. Steven Gallinger, a surgical oncologist at Mount Sinai Hospital and University Health Network, as well as Professor of Surgery at University of Toronto. "Yet, for nearly 17 per cent of colon cancer patients, the traditional chemotherapy treatment is not helpful, and may even be harmful."

The study, which also involved doctors and researchers from the United States and France, shows that further investigation is needed to provide alternatives for these patients, such as new drugs that are effective on tumors with high-frequency microsatellite instability.

Testing for this genetic mutation could easily become a regular routine during diagnosis, with the results being used to direct the rational use of chemotherapy in colon cancer.

"Undergoing chemotherapy is not an easy decision. Side effects can include sore throat and mouth, tiredness, increased risk of infection, and in a small number of cases, even serious life-threatening illness," said Dr. Malcolm Moore, a Princess Margaret Hospital medical oncologist involved in the study. "If we can select the patients most likely to benefit from therapy, we can restrict therapy to that population and spare the remaining patients the trauma of that type of treatment."

Vince Rice | EurekAlert!
Further information:
http://www.utoronto.ca

More articles from Health and Medicine:

nachricht Research offers clues for improved influenza vaccine design
09.04.2018 | NIH/National Institute of Allergy and Infectious Diseases

nachricht Injecting gene cocktail into mouse pancreas leads to humanlike tumors
06.04.2018 | University of Texas Health Science Center at San Antonio

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

Im Focus: The Future of Ultrafast Solid-State Physics

In an article that appears in the journal “Review of Modern Physics”, researchers at the Laboratory for Attosecond Physics (LAP) assess the current state of the field of ultrafast physics and consider its implications for future technologies.

Physicists can now control light in both time and space with hitherto unimagined precision. This is particularly true for the ability to generate ultrashort...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Diamond-like carbon is formed differently to what was believed -- machine learning enables development of new model

19.04.2018 | Materials Sciences

Electromagnetic wizardry: Wireless power transfer enhanced by backward signal

19.04.2018 | Physics and Astronomy

Ultrafast electron oscillation and dephasing monitored by attosecond light source

19.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>