Discovery may lead to targeted therapies to interrupt cancer development
Principal investigator Craig Thompson, MD (right), shows immunologist Casey Fox, PhD, images of gel results (dark bands) of surviving cancer cells when enzyme Pim-2 is present. Their latest research into the origins of cancer is published in the August 1 edition of Genes & Development. Abramson Family Cancer Research Institute, University of Pennsylvania (2003)
(Philadelphia, PA) – Researchers at the Abramson Family Cancer Research Institute at the University of Pennsylvania have determined that a key enzyme, Pim-2, is responsible for the survival of cancer cells. The finding – which will appear in the August 1 edition of the journal Genes & Development – represents an important advance in understanding why cancer cells survive in the body (working against the bodys natural immune system), before growing into tumors. It also answers a 20-year-old question as to the purpose of Pim-2, an enzyme present in high concentrations in many tumors, but left unstudied to this time; and it equates Pim-2 with another, more commonly studied survival pathway, the Akt-enzyme pathway.
"This finding is important because it shows, for the first time, how Pim-2 works and its key role in cancer cell survival," said Craig Thompson, MD, Principal Investigator of the study and Scientific Director of the Abramson Family Cancer Research Institute (AFCRI). "Up until now, predominant thinking has looked to the Akt pathway as the primary pathway for cancer cells. Now we know that Pim-2 plays an equally important role – and it is as much of a cancer-promoting gene, or oncogene, as Akt.
David March | EurekAlert!
Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences