In their quest for a vaccine that may one day routinely protect against heart attacks and strokes, cardiologists at Cedars-Sinai Medical Center and their colleagues in Sweden have isolated a key step in the mechanism that leads to vascular plaque buildup and blood clot formation.
In mice genetically predisposed to quickly develop atherosclerosis, the researchers were able to trigger a protective immune response, significantly increasing the level of immunoglobulin gamma G (IgG), an antibody known to be important in protection against atherosclerosis. Immunization resulted in reduction of atherosclerosis by about 60 percent, compared with controls.
Heart disease is well established as the nations leading cause of death, and atherosclerosis is one of the major risk factors. Over the past several years, evidence has mounted that infection and inflammation contribute to this process. Researchers hope, therefore, that by attacking the first link in a complex chain of events, they can shut down a deadly process before it begins.
Sandra Van | Van Communications
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Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
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