Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cadmium’s disguise does damage to estrogen-sensitive tissues

16.07.2003


With 15,000 tons produced each year for batteries, alloys, and pigments, the heavy metal cadmium is one of the most serious environmental pollutants. Chronic exposure can induce kidney damage and bone disease and is thought to cause cancer. A study in the August issue of Nature Medicine now shows that cadmium mimics the effects of estrogen, and suggests that even at relatively low doses cadmium might have wide-ranging effects on the body.

Mary Beth Martin and colleagues report that, in rats, cadmium induces several well-known estrogenic responses. These included increased uterine weight, changes in the endometrial lining and increased density of the epithelia of the mammary gland. Moreover, in utero exposure to cadmium affected mammary gland development and onset of puberty in female offspring. The results provide solid evidence that cadmium has estrogenic effects in the whole animal, and follow up on earlier studies reporting that cadmium and other heavy metals such as nickel interact with the estrogen receptor. The new data also broaden the toxic repertoire of cadmium, which is a known kidney toxin, and was recently shown (Jin et al., Nat. Genet. 34, 326–329; 2003) to impair DNA repair processes in yeast.

The investigators did not perform dose-response studies but they found that cadmium induced potent estrogenic responses in rats at doses (5–10 micrograms per kilogram total weight) comparable to the Provisional Tolerable Weekly Intake recommended by the World Health Organization (7 micrograms per kilogram per week). In addition to pinpointing another mechanism for some of cadmium’s effects, the new data could call into question current regulatory standards for cadmium exposure.



Author contact:

Mary Beth Martin
Georgetown University, Washington, DC, USA
Tel: +1 202 687 3768
E-mail: martinmb@georgetown.edu

Jo Webber | alfa
Further information:
http://www.nature.com/naturemedicine

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>