Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Microbubbles can image blood vessel growth in tumors

16.07.2003


Imagine being able to quickly detect and diagnose blood vessel growth in cancerous tumors, and even predict how fast the tumors might metastasize or spread. Researchers at the University of Virginia Health System are doing just that in animal models using millions of tiny microbubbles injected into the bloodstream, coupled with contrast-enhanced ultrasound, an inexpensive and widely-used technique using sound waves to "see" inside the body.

Their findings are published in the July 22 edition of the journal Circulation.

"For the first time, this research shows that scientists can detect cancer using ultrasound contrast agents targeted to abnormal blood vessels that reside within tumors," said Dr. Jonathan Lindner, a U.Va. cardiologist and primary author of the study. "By assessing how much new blood vessel growth there is, we can detect tumors and metastatic spread at a very early stage."



Lindner said the one of the first signs of tumor and metastasis is a remodeling of surrounding blood vessels in the normal tissue near a tumor. The tumor activates the process of growth of new blood vessels called angiogenesis, supplying nutrients and oxygen to the tumor and keeping it alive.

To detect angiogenesis in and around a tumor, Dr. Lindner’s research group developed microbubbles targeted to the endothelial (inner) lining of new blood vessels. Microbubbles are normally about half the size of a red blood cell and are composed of a gas surrounded by a shell. They are currently being used worldwide to image blood flow and heart function in patients.

In their experiments, Lindner’s team at U.Va. attached molecules of echistatin, derived from viper venom, to the surface of each microbubble and injected the bubbles intravenously into mice with brain tumors. The echistatin molecule caused the bubbles to bind to a molecular component (an integrin) called alpha-v beta-3, which is expressed in the lining, or endothelium, of new blood vessels. After just ten minutes, the targeted microbubbles, and new blood vessels, appeared in bright colors on an ultrasound image.

"We may soon be able to assess cancer prognosis on patients using a technique like this. The more angiogenesis, the more aggressive a tumor is likely to be," Lindner said. "This microbubble technique may be able to tell people and their physicians exactly what’s likely to happen with a tumor in the future. If we know it has a certain amount of angiogenesis, then we know a tumor might be susceptible to treatment with new anti-tumor or anti-neoplastic agents developed to shrink tumors."

The U.Va. researchers were also able to use microbubbles to image capillary blood flow in tumors. They found that blood flow has a high velocity on the periphery of the tumors, but a much slower velocity inside a tumor. Blood flow velocity is a potentially important marker for tumor detection, Lindner said.

Linder and his U.Va. team first used microbubbles to detect angiogenesis in animal models, but not tumors. Their earlier findings were published in the January 28, 2003 edition of Circulation.

Bob Beard | EurekAlert!
Further information:
http://circ.ahajournals.org
http://hsc.virginia.edu/news

More articles from Health and Medicine:

nachricht Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital

nachricht New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Long-lived storage of a photonic qubit for worldwide teleportation

12.12.2017 | Physics and Astronomy

Multi-year submarine-canyon study challenges textbook theories about turbidity currents

12.12.2017 | Earth Sciences

Electromagnetic water cloak eliminates drag and wake

12.12.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>