In the July 15 issue of The Journal of Clinical Investigation, Ambrose Cheung and colleagues at Dartmouth School of Medicine in New Hampshire, USA, report that salicylic acid (SAL), the major metabolite of aspirin, downregulates two Staphylococcus aureus genes key to this organisms pathogenesis.
Over 100 years have passed since S. aureus was first described as the organism responsible for causing sepsis and abscesses. Today it remains a leading cause of serious infections such as endocarditis, pneumonia, and septicemia and requires intensive antibiotic therapy, which is often unsuccessful due to the rise of antibiotic resistant strains.
Aspirin has previously been shown to reduce the virulence of S. aureus in models of endocarditis. In an earlier study, this same group found that while administration of aspirin or its metabolite, SAL, was capable of reducing the ability of S. aureus to attach to host cells, the effect was significantly enhanced following SAL administration.
Brooke Grindlinger | EurekAlert!
World first: Massive thrombosis removed during early pregnancy
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Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....
A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...
Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision
Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...
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