Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

An aspirin a day keeps Staphylococcus aureus away

16.07.2003


In the July 15 issue of The Journal of Clinical Investigation, Ambrose Cheung and colleagues at Dartmouth School of Medicine in New Hampshire, USA, report that salicylic acid (SAL), the major metabolite of aspirin, downregulates two Staphylococcus aureus genes key to this organism’s pathogenesis.



Over 100 years have passed since S. aureus was first described as the organism responsible for causing sepsis and abscesses. Today it remains a leading cause of serious infections such as endocarditis, pneumonia, and septicemia and requires intensive antibiotic therapy, which is often unsuccessful due to the rise of antibiotic resistant strains.

Aspirin has previously been shown to reduce the virulence of S. aureus in models of endocarditis. In an earlier study, this same group found that while administration of aspirin or its metabolite, SAL, was capable of reducing the ability of S. aureus to attach to host cells, the effect was significantly enhanced following SAL administration.


In this issue of the JCI, Cheung and colleagues extend these earlier findings and report that treatment with SAL induced activation of the S. aureus stress response gene sigB, resulting in downregulation of regulons sarA and agr, which control the expression of the genes encoding a-hemolysin and fibronectin. This downregulation resulted in decreased ability of the bacteria to adhere to host cells, and reduced S. aureus toxin-mediated hemolysis and thrombolysis of host cells.

"The establishing of a straightforward, unequivocal strategy to downregulate staphylococcal virulence using a cheap, simple, relatively non-toxic, resorbable compound such as SAL may be seen as major progress in the development of intervening strategies in addition to antimicrobial drugs" stated Professor Mathias Herrmann, Director of the Department of Bacteriology and Hygiene at the University of Saarland, Germany in his accompanying commentary. The report is the first description of aspirin-mediated genetic effects against S. aureus and represents an exciting new prospect for this widely used and established drug.

Contact:

Ambrose L. Cheung
Dartmouth Medical School, Hanover, New Hampshire, USA.
Phone: 603-650-1310
Fax: 603-650-1362
Email: ambrose.cheung@dartmouth.edu


Mathias Herrmann
University of Saarland Hospital, Homburg/Saar, Germany.
Phone: 49-6841-162-3900
Fax: 49-6841-162-3985
Email: mathias.herrmann@uniklinik-saarland.de

Brooke Grindlinger | EurekAlert!
Further information:
http://www.jci.org

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Strathclyde-led research develops world's highest gain high-power laser amplifier

The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.

The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

New insights into the ancestors of all complex life

29.05.2017 | Earth Sciences

New photocatalyst speeds up the conversion of carbon dioxide into chemical resources

29.05.2017 | Life Sciences

NASA's SDO sees partial eclipse in space

29.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>