Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UCSD Researchers Find Brain Overgrowth During First Year of Life in Autism

16.07.2003


Small head circumference at birth, followed by a sudden and excessive increase in head circumference during the first year of life, has been linked to development of autism by researchers at the University of California, San Diego (UCSD) School of Medicine and Children’s Hospital and Health Center, San Diego. Autism spectrum disorder occurs in one out of every 160 children and is among the more common and serious of neurological disorders of early childhood.


Researchers found rapid, excessive brain growth in infants later identified with autism spectrum disorder.


Courchesne discusses the JAMA study with co-authors Ruth Carper, Ph.D., left, and Natacha Akshoomoff, Ph.D., standing



Published in the July 16, 2003 issue of the Journal of the American Medical Association (JAMA), the study identifies the first neurobiological, early-warning signs of autism during a child’s first year of life, and offers the potential for earlier diagnosis, intervention and improved clinical outcomes for autistic children. In addition, this dramatic brain overgrowth is expected to become a major focus of future autism genetics research.

The early-warning sign – abnormally accelerated rate of head, and therefore brain, growth – occurs well before the first clinical signs of autism. It also appears to predict the severity of clinical outcome as well as the degree of brain abnormality at a later age. Currently, the disorder is not typically detected until ages two to four, when a child develops behavioral signs and symptoms, such as delayed speech, unusual social and emotional reactions, and poor attention to and exploration of the environment.


The investigators noted that this rapid, excessive brain growth in infants with autism does not allow enough time for accumulation of experiences and emotions that guide and shape normal behavior.

"During this period of important learning and plasticity, when the brain is experiencing the world and deciding how to construct itself, it’s growing too fast in the infant with autism," said the study’s senior author Eric Courchesne, Ph.D., UCSD professor of neurosciences and director of the Center for Autism Research at Children’s. "Without the guidance of experience and learning, the brain may be creating abnormal connections that make it very hard for autistic children to make sense of the world they live in."

The research team also found that the rate of excessive brain growth predicted the severity of autism. Children later diagnosed with a more severe form demonstrated a faster, and greater rate of brain overgrowth during their first year of life, compared to that of children with a milder form of the disorder.

Noting that the new findings offer strategies for earlier diagnosis and treatment, study co-author Natacha Akshoomoff, Ph.D., said "previous studies have shown that early therapeutic services result in a better outcome for the child. These usually include speech and occupational therapy, plus communication and social skill building. However, currently there are no biological or medical interventions for children identified with autism."

Akshoomoff is a UCSD assistant professor of psychiatry, and assistant research scientist at Children’s.

In studying the medical records of 48 two- to five-year olds who have been diagnosed with autism spectrum disorders, the research team recruited volunteers from community advertisements and referrals. Each of the children in the study had been a participant in previous MRI studies reporting age-related changes in the brain in autism. The children’s head circumference measurements at birth and during various points in their first year of life were compared to the Centers for Disease Control and Prevention growth charts for normal children and to the Fels Longitudinal Study of head circumference in 51 infants born between 1980 and 2001.

It was found that the head size of the autistic children at birth was, on average, in the 25th percentile, meaning that the circumference measurement for these children was smaller than 75 percent of other newborns. During the first year of life, however, these same children experienced sudden, rapid and excessive brain growth, that put them in the 85th percentile at about 12- to 14-months of age. From then on, the brain growth slowed.

"This burst of overgrowth takes place in a brief period of time, between about two months and six to 14 months of age," Courchesne said. "So, we know it cannot be caused by events that occur later, such as vaccinations for mumps, measles and rubella or exposure to toxins during childhood."

Although no one has yet determined the biological cause of autism, the new findings "give us information about the timing of abnormal brain development," said study co-author Ruth Carper, Ph.D., a post-doctoral researcher in the UCSD Department of Neurosciences and a research associate at Children’s. "This provides a timeframe for further research, to determine the exact brain abnormalities and the biological mechanisms which produce them."

"This dramatic brain growth in early life is the first active neuro-developmental process to be discovered in infants with autism," Courchesne added. "It provides, for the first time, a developmental process to target for animal model studies of the disorder. Animal models that accurately mimic these abnormal growth events will be necessary in order to discover causes and biological treatments for autism. Once we know what causes this specific growth defect, it may be possible to use biological treatments to successfully intervene before the overgrowth begins, thereby allowing the brain and behavior to develop down more normal paths."

Although some conditions, such as hydrocephalus or certain types of metabolic disorders, cause a large head circumference in the first year of life, these clinical conditions are much less common than autism spectrum disorders, which occur in as many as one out of every 160 children. According to the Autism Society of America, more than a million Americans (including adults) suffer from an autistic disorder.

The correlation between rapid brain growth and the behavioral manifestations seen in autistic children was also discussed in the JAMA paper. The three authors noted that "this early, yet transient, period of brain overgrowth must be an important factor in causing the emergence of autistic behavior because it occurs at the beginning of an important period of developmental neuroplasticity and learning."

Research has shown that the developing human brain is designed to benefit from an extended period of experience-guided growth. In the study, the researchers noted that sensations, emotions, thoughts and actions direct the brain’s axonal and dendritic growth, creating, reinforcing or eliminating brain synapses as needed. Eventually, these experiences lead to the emergence of refined higher order neurobehavioral functions, such as cognitive, emotional, linguistic and motor skills.

"Using our findings as an early indicator of autism, intervention might begin two or three years earlier when the brain might be at a more malleable stage and so, might result in a better outcome for the child," Courchesne said.

And, all it takes is a simple, low-tech tape measure. Unfortunately, not all infants get their head circumference measured on a regular basis, Akshoomoff noted.

"Although nearly all hospitals measure a newborn’s head circumference, this measurement is sometimes not included in each well-baby visit," she said. "If pediatricians include head circumference measurements routinely throughout the first year of life, and use up-to-date head circumference norms, they might notice a rapid growth, and could then refer the child for thorough diagnostic testing and possible early intervention services."

The research team, directed by Courchesne, plans to expand this study to a larger group of children, to better determine the timing of brain mal-development. This will include sophisticated MRI studies that follow children under age three for several years.

The JAMA study was supported by a grant from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health.

UCSD and Children’s Hospital have an affiliated children’s health program that includes pediatric patient care, research, education and community service programs

Sue Pondrom | UCSD
Further information:
http://health.ucsd.edu/news
http://www.ucsd.edu

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>