A University of Minnesota study has confirmed the pivotal role of an enzyme known as JNK2 in the development of nonmelanoma skin cancers. The findings suggest that JNK2 should be evaluated as a target for the prevention and treatment of such cancers. Lead author Zigang Dong, director of the university’s Hormel Institute in Austin, Minn., will present the work at 8:30 a.m. Sunday, July 13, at the American Association for Cancer Research meeting in the Washington Convention Center, 801 Mount Vernon Place NW, Washington, D.C.
Ultraviolet rays from the sun are the major culprit in skin cancer, which accounts for more than half the cancers in the United States. The process of cancer development involves a chain of interactions among biochemicals in the skin, and biochemicals that play key roles in carcinogenesis make potential therapeutic targets. Many human cancers show elevated activity in some form of JNK enzyme, and the enzyme is also activated by sunlight, Dong said.
"Even if one goes into the sun for a few minutes, the activity of JNK in the epidermis rises," said Dong. "If you go out for a few minutes, JNK activity doesn’t stay elevated. But it looks as though if a person gets too much sun exposure, JNK activity becomes permanently elevated and cancers develop. This study indicates that some form of JNK activity is a key step in the process by which nonmelanoma cancers grow."
Deane Morrison | EurekAlert!
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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