A University of Minnesota study has confirmed the pivotal role of an enzyme known as JNK2 in the development of nonmelanoma skin cancers. The findings suggest that JNK2 should be evaluated as a target for the prevention and treatment of such cancers. Lead author Zigang Dong, director of the university’s Hormel Institute in Austin, Minn., will present the work at 8:30 a.m. Sunday, July 13, at the American Association for Cancer Research meeting in the Washington Convention Center, 801 Mount Vernon Place NW, Washington, D.C.
Ultraviolet rays from the sun are the major culprit in skin cancer, which accounts for more than half the cancers in the United States. The process of cancer development involves a chain of interactions among biochemicals in the skin, and biochemicals that play key roles in carcinogenesis make potential therapeutic targets. Many human cancers show elevated activity in some form of JNK enzyme, and the enzyme is also activated by sunlight, Dong said.
"Even if one goes into the sun for a few minutes, the activity of JNK in the epidermis rises," said Dong. "If you go out for a few minutes, JNK activity doesn’t stay elevated. But it looks as though if a person gets too much sun exposure, JNK activity becomes permanently elevated and cancers develop. This study indicates that some form of JNK activity is a key step in the process by which nonmelanoma cancers grow."
Deane Morrison | EurekAlert!
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy