Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New target for skin cancer confirmed

14.07.2003


A University of Minnesota study has confirmed the pivotal role of an enzyme known as JNK2 in the development of nonmelanoma skin cancers. The findings suggest that JNK2 should be evaluated as a target for the prevention and treatment of such cancers. Lead author Zigang Dong, director of the university’s Hormel Institute in Austin, Minn., will present the work at 8:30 a.m. Sunday, July 13, at the American Association for Cancer Research meeting in the Washington Convention Center, 801 Mount Vernon Place NW, Washington, D.C.

Ultraviolet rays from the sun are the major culprit in skin cancer, which accounts for more than half the cancers in the United States. The process of cancer development involves a chain of interactions among biochemicals in the skin, and biochemicals that play key roles in carcinogenesis make potential therapeutic targets. Many human cancers show elevated activity in some form of JNK enzyme, and the enzyme is also activated by sunlight, Dong said.

"Even if one goes into the sun for a few minutes, the activity of JNK in the epidermis rises," said Dong. "If you go out for a few minutes, JNK activity doesn’t stay elevated. But it looks as though if a person gets too much sun exposure, JNK activity becomes permanently elevated and cancers develop. This study indicates that some form of JNK activity is a key step in the process by which nonmelanoma cancers grow."



Working with mice, Dong and his colleagues focused on two enzymes known to be activated by factors that cause cells to divide and that have been considered important in skin cells’ response to UV light. Of the two enzymes, called JNK1 and JNK2, only the latter turned out to play an important role in the development of tumors.

The researchers used two lines of mice that had been rendered enzyme-deficient by inactivation of the gene for either JNK1 or JNK2 in fertilized mouse eggs. When the mice were two months old, the scientists applied a chemical carcinogen to the skin of their backs, followed by five-times-a-week exposure to UVB light, the ultraviolet light that causes skin cancer. At 31 weeks of age, a much smaller percentage of JNK2-deficient mice had tumors (18 percent), compared to control mice (48 percent) or JNK1-lacking mice (50 percent). At 40 weeks of age, the percentage of tumor-bearing JNK2-deficient mice had almost doubled, to 35 percent, while the percentage rose more slowly in control mice (to 56 percent) and JNK1-deficient mice (to 73 percent).

The data suggest that when JNK2 is lacking, skin cells are inhibited, or at least delayed, in their response to UVB light.

"Knocking out the JNK2 enzyme could simply delay the response to ultraviolet light, but if so, it would be significant," Dong said. "If we age enough, every one of us will get cancer. But if we can delay the process, that’s good progress."

The researchers also studied the biochemistry of skin and embryonic cells from the mice. They found that UVB light and a chemical known to promote tumor formation induced biochemical activity associated with cell division and tumor growth in control mice and JNK1-deficient mice, but not in JNK2-deficient mice.


The work was supported by the National Institutes of Health.


Contacts:

Zigang Dong, Hormel Institute director, (507) 437-9600

Deane Morrison, University News Service, (612) 624-2346

Deane Morrison | EurekAlert!
Further information:
http://www.umn.edu/

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>