Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Studies demonstrate differing response from left and right colon tumors

14.07.2003


Significant genetic differences exist between tumors of the right and left side of the colon, according to data presented today at the 94th Annual Meeting of the American Association for Cancer Research (AACR), and these distinctions should be considered for future research and treatment.



"With emerging treatments directed toward specific molecular targets, there should be special emphasis on such an important differentiation," said Sanne Olesen, M.Sc. of biology, Aarhus University Hospital, Denmark, and lead investigator of the study conducted by scientists from Denmark and Finland. "Hopefully with this new understanding of the differences that exist in the colon, we can more efficiently treat cancer patients."

In the study, approximately 6,800 known genes were monitored for activity. Twenty single samples of normal colonic mucosa were compared to 25 single cancerous samples from both the left and right sides of the colon. Findings were validated by semi-quantitative, RealTime-PCR and immunohistochemistry, or observations of clinical reactions to the immune system.


Scientists found 58 genes that were dissimilar between the normal samples and the left-sided tumor samples, and 118 genes between the normal samples and the right-sided tumor samples. An additional 44 unique genes were found between the right- and left-sided tumor samples. Furthermore, scientists identified 30 genes which showed parallel expression in both sides, and therefore may be regarded as general tumor markers.

"This discovery may explain why some colorectal patients have responded to treatment while others did not," said Dr. Torben Orntoft, a professor at Aarhus University. "With new targeted therapies in development, our patients have a better chance of survival."

Colon cancer is one of the most common cancers found in men and women today. The American Cancer Society estimates that in 2003 there will be about 105,500 new cases of colon cancer in the United States, causing over 57,000 deaths


Founded in 1907, the American Association for Cancer Research (AACR) is a professional society of more than 20,000 laboratory and clinical scientists engaged in cancer research in the United States and more than 60 other countries. AACR’s mission is to accelerate the prevention and cure of cancer through research, education, communication and advocacy. Its principal activities include the publication of five major peer-reviewed scientific journals (Cancer Research; Clinical Cancer Research; Molecular Cancer Therapeutics; Molecular Cancer Research; and Cancer Epidemiology, Biomarkers & Prevention). AACR’s annual meeting attracts more than 12,000 participants who share new and significant discoveries in the cancer field, and the AACR’s specialty meetings throughout the year focus on all the important areas of basic, translational and clinical cancer research.


Contact: Warren Froelich/AACR
froelich@aacr.org
215/440-9300


Aimee Frank/Spectrum Science
amf@spectrumscience.com
202/955-6222

In Washington, DC: (7/11-7/14)
Washington Convention Center
202/249-4060

Warren Froelich | EurekAlert!

More articles from Health and Medicine:

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

nachricht High speed video recording precisely measures blood cell velocity
15.11.2017 | ITMO University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>