Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Slide Projector Kills Herpes Simplex Virus

04.07.2003


A lot of people suffer from herpes for all their lives. The herpes simplex virus (Type 1) constantly inhabits the organism revealing its presence from time to time. Once highly active anti- herpes drugs were developed (acyclovir and phosofonoacetic acids), the virus responded with new forms resistant to theses drugs. The Belorus researchers from the State Scientific Research Institute of Epidemiology and Microbiology, Ministry of Health, Republic of Belorus, and the Institute of Photobiology, National Academy of Sciences of Belorus, have suggested to fight these mutant viruses by the photodynamic inhibition method.



The method is based on the photosensitive reactions, which take place in biological systems. Researchers all over the world are actively developing new methods based on these reactions to cure various diseases. The essence of the method is that photosensitizer substances interact with the sick cells or infection pathogene. The above substances get destroyed under the influence of the visible light and form free radicals, including active forms of oxygen, which easily oxidize proteins, lipids and other biologically important molecules. Photosensitizers are of different types, but the Minsk researchers have chosen merocyanins, which bundle with diverse viral shells including the herpes simplex virus (Type 1).

The experiments were carried out with the cell culture of the kidney of the African green talapoin (Cercopithecus aethiops), infected by the herpes simplex virus (Type 1). Consequences of infection can be noticed already in 4-5 hours: the cells start to divide intensely, they merge with each other, foreign impurities appear in them, besides there are other typical indications perfectly visible through a microscope. Within 48-56 hours, the cells take the shape of a ball, flake away from the walls of a flask where they were grown up and all of them get killed. It was decided to annihilate the infected cells.


The cells of the green talapoin interact well with ? merocyanin MC 540 (about a billion molecules of photosensitizer bundle with each cell). Bundling of merocyanin MC 540 with infected cells depends on the stage of infection: it increases by approximately 22%, when the virus sticks round the cell, at the early stages of virus reproduction bundling remains on the same level and it decreases when virus particles get mature. Viruses synthesize their proteins with the help of the cell captured by them, due to that the cellular membrane structure slightly changes and acquires increased affinity with merocyanin. Thanks to that, infected cells actively interact with merocyanin MC 540, that is why they can be annihilated more or less selectively. The researchers have selected such a sensitizing agent doze and lighting conditions which annihilate mainly infected cells. For lighting, the researchers used a common slide-projector “Peleng 500 ?” (KGM lamp, 150 Wt).

The cells infected by the herpes virus culture mutants insensitive to traditional drugs die. The virus is incapable of propagating itself in the dying cells, and this the way the researchers plan to stop the infection development. The scientists assume that thephotosensitizer damages not only infected cells, but the viruses as well. According to the researchers, the photodynamic therapy may become an efficient remedy capable to stop herpes virus infections. It is most important to utilize this therapy in clinical practice, if the patients are infected with a virus resistant to the drugs. However, it is still a long way to go from the dish with the green talapoin’s cells culture through to clinical trials and particularly practice.

Sergey Komarov | alfa
Further information:
http://www.informnauka.ru

More articles from Health and Medicine:

nachricht Tracking movement of immune cells identifies key first steps in inflammatory arthritis
23.01.2017 | Massachusetts General Hospital

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>