Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Slide Projector Kills Herpes Simplex Virus

04.07.2003


A lot of people suffer from herpes for all their lives. The herpes simplex virus (Type 1) constantly inhabits the organism revealing its presence from time to time. Once highly active anti- herpes drugs were developed (acyclovir and phosofonoacetic acids), the virus responded with new forms resistant to theses drugs. The Belorus researchers from the State Scientific Research Institute of Epidemiology and Microbiology, Ministry of Health, Republic of Belorus, and the Institute of Photobiology, National Academy of Sciences of Belorus, have suggested to fight these mutant viruses by the photodynamic inhibition method.



The method is based on the photosensitive reactions, which take place in biological systems. Researchers all over the world are actively developing new methods based on these reactions to cure various diseases. The essence of the method is that photosensitizer substances interact with the sick cells or infection pathogene. The above substances get destroyed under the influence of the visible light and form free radicals, including active forms of oxygen, which easily oxidize proteins, lipids and other biologically important molecules. Photosensitizers are of different types, but the Minsk researchers have chosen merocyanins, which bundle with diverse viral shells including the herpes simplex virus (Type 1).

The experiments were carried out with the cell culture of the kidney of the African green talapoin (Cercopithecus aethiops), infected by the herpes simplex virus (Type 1). Consequences of infection can be noticed already in 4-5 hours: the cells start to divide intensely, they merge with each other, foreign impurities appear in them, besides there are other typical indications perfectly visible through a microscope. Within 48-56 hours, the cells take the shape of a ball, flake away from the walls of a flask where they were grown up and all of them get killed. It was decided to annihilate the infected cells.


The cells of the green talapoin interact well with ? merocyanin MC 540 (about a billion molecules of photosensitizer bundle with each cell). Bundling of merocyanin MC 540 with infected cells depends on the stage of infection: it increases by approximately 22%, when the virus sticks round the cell, at the early stages of virus reproduction bundling remains on the same level and it decreases when virus particles get mature. Viruses synthesize their proteins with the help of the cell captured by them, due to that the cellular membrane structure slightly changes and acquires increased affinity with merocyanin. Thanks to that, infected cells actively interact with merocyanin MC 540, that is why they can be annihilated more or less selectively. The researchers have selected such a sensitizing agent doze and lighting conditions which annihilate mainly infected cells. For lighting, the researchers used a common slide-projector “Peleng 500 ?” (KGM lamp, 150 Wt).

The cells infected by the herpes virus culture mutants insensitive to traditional drugs die. The virus is incapable of propagating itself in the dying cells, and this the way the researchers plan to stop the infection development. The scientists assume that thephotosensitizer damages not only infected cells, but the viruses as well. According to the researchers, the photodynamic therapy may become an efficient remedy capable to stop herpes virus infections. It is most important to utilize this therapy in clinical practice, if the patients are infected with a virus resistant to the drugs. However, it is still a long way to go from the dish with the green talapoin’s cells culture through to clinical trials and particularly practice.

Sergey Komarov | alfa
Further information:
http://www.informnauka.ru

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>