Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Drug improves the sense of touch, Science study says

04.07.2003


Scientists used a stimulation technique to improve the sensitivity of people’s fingertips, and then gave them drugs that either doubled or deleted this effect. Similar skin stimulation/drug treatment combinations may eventually help the elderly or stroke victims button shirts and aid professional pianists according to the authors of a paper appearing in the 04 July issue of the journal Science, published by AAAS, the science society.



Finger stimulations and drugs can temporarily reorganize parts of the human brain. This stimulation, called co-activation, shuffles the synapses that link neurons. The stimulated area becomes more sensitive as more neurons are recruited to process encountered tactile information. The scientists showed that amphetamine doubled stimulation-induced gains in tactile acuity. In the presence of an alternate drug, an NMDA blocker, the improvements in tactile acuity, or perceptual learning, gained via finger stimulations were lost.

Dinse said that related treatments could improve a person’s ability to read Braille and that drug-mediated muscle stimulation could help the elderly and chronic pain patients perform everyday tasks.


"We are at the beginning of an era where we can interact with the brain. We can apply what we know about brain plasticity to train it to alter behavior. People are always trying to find ways to improve learning. What we tested is unconscious skill learning. How far could this carry to cognitive learning?…that remains to be seen," said Dinse.

"My personal opinion," Dinse maintained, "is that progress in brain pharmacology will sooner or later result in implications that are equally or possibly more dramatic than the implications tied to discussions about genes and cloning."

To understand tactile acuity, imagine closing your eyes and running your hands over a boulder. A high degree of tactile acuity translates into the ability to sense lots of variety in the textures of the rock.

To quantify changes in tactile acuity, the researchers dropped the distance between two pins pressing against human skin. At some distance, people can no longer detect two distinct pressure points on the tips of their index fingers.

Monitoring changes in the minimum distance that still allows for two-point detection provides a measure of tactile acuity and perceptual learning.

Dinse explained that the cortex of the human brain has both a sensory and a motor "body map." Using these maps unconsciously, humans navigate through the physical world.

"We are now finding ways to interact with the brain’s body maps. This has enormous power," said Dinse who explained that manipulating body maps housed in the brain can have an immediate impact on behavior and perception.

The brain modifies its body maps as a basic tool for learning and adapting to new situations. This disconnecting and reconnecting of neurons is known as synaptic plasticity.

In an attempt to alter their sensory body maps, participants wore an eight millimeter disc for three hours that stimulated a patch of skin on tips of their right index fingers. This coactivation boosts the number of neurons involved in processing tactile information coming from the area of stimulated skin. By this method, external stimulation to finger tips temporarily reorganized part of the cortex and modified the sensory body maps of the participants.

After 24 hours, the enhanced ability to detect pin points dropped to normal levels. Dinse noted that further coactivation of the same area quickly reestablished the heightened tactile acuity. With the goal of rehabilitation treatments in mind, Dinse is currently looking for ways to make the improved sensory reception more durable and long lasting.

The coactivation protocol described in this study requires no active participation by the participant and this makes it an attractive therapeutic approach, according to Dinse.

"In past experiments, we tested coactivation in people between 65 and 90 years old. The coactivation temporarily improved tactile acuity with little harassment to the subjects," said Dinse. "According to our new findings, certain drugs can enhance the effects of coactivation. The drug component makes this coactivation approach even more promising."



Hubert. R. Dinse, Patrick Ragert, Burkhard Pleger, Peter Schwenkreis and Martin Tegenthoff are from Ruhr-U. Bochum in Bochum, Germany.

Funding for this research was provided in part by the Deutsche Forschungsgemeinschaft (grant no.Di334/10-3 to Hubert Dinse and MartinTegenthoff and grant no. Di334/15 to Hubert Dinse) and by a grant of the Heinrich-und-Alma-Vogelsang-Stiftung to Peter Schwenkreis.

Founded in 1848, the American Association for the Advancement of Science (AAAS) has worked to advance science for human well-being through its projects, programs, and publications, in the areas of science policy, science education and international scientific cooperation. AAAS and its journal, Science, report nearly 140,000 individual and institutional subscribers, plus 272 affiliated organizations in more than 130 countries, serving a total of 10 million individuals. Thus, AAAS is the world’s largest general federation of scientists. Science is an editorially independent, multidisciplinary, peer-reviewed weekly that ranks among the world’s most prestigious scientific journals. AAAS administers EurekAlert!, the online news service, featuring the latest discoveries in science and technology.

Daniel Kane | EurekAlert!

More articles from Health and Medicine:

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

nachricht High speed video recording precisely measures blood cell velocity
15.11.2017 | ITMO University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>