Discovery offers ‘new hope to patients by paving the way for future therapies that will change the course of hepatitis’
A protein molecule that contributes to the severity of chronic viral hepatitis in humans, and which may also be implicated in SARS, has been identified by a team of scientists from Toronto General and St. Michaels Hospitals. This data is published in the July 1 issue of the Journal of Clinical Investigation.
The protein, called Fgl2/fibroleukin prothrombinase, is a newly discovered protein which causes blood to clot in the livers of humans with viral hepatitis. In animal trials, this same protein causes blood to clot in the livers of mice that are exposed to the corona virus.
This work was funded by grants from the Canadian Institute of Health Research, Heart and Stroke Foundation of Canada, and Dr. Levy is the recipient of the CIHR Novartis Research Chair in Transplantation.
St. Michaels Hospital is a Catholic teaching and research hospital, fully affiliated with the University of Toronto, specializing in inner city health, heart and vascular disease, trauma/neurosurgery, diabetes comprehensive care, minimal access therapeutics, and neurological and musculoskeletal disorders.
Toronto General Hospital is a partner in University Health Network, along with Toronto Western and Princess Margaret Hospitals. The scope of research and complexity of cases at Toronto General Hospital has made it a national and international source for discovery, education and patient care. It has one of the largest hospital-based research programs in Canada, with major research projects in cardiology, transplantation, surgical innovation, infectious diseases, and genomic medicine. Toronto General Hospital is a teaching hospital affiliated with the University of Toronto.
To arrange interviews with Dr. Levy, please contact:
Alex Radkewycz or Kim Garwood, Public Affairs
Toronto General Hospital, University Health Network
Phone: Alex - 416-340-3895
Kim - 340-4800 ext. 6753
To arrange interviews with Dr. Philip Marsden, please contact:
Tracy MacIsaac, Media Relations
St. Michaels Hospital
Page (via locating): 416-864-5431
Tracy MacIsaac | EurekAlert!
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