A research study under way at Northwestern Memorial Hospital is trying to find out if the popular anti-inflammatory drug Celebrex might do more than ease arthritis pain. Researchers at Northwestern Memorial are enrolling patients with early stage head and neck cancers or non-small cell lung cancers in a research study to see if Celebrex reduces the return of old tumors or the chance of getting a new cancer when taken after surgery or radiation treatments.
The double-blind, randomized study will enroll about 120 patients at Northwestern Memorial, the primary teaching hospital of Northwestern Universitys Feinberg School of Medicine. Celebrex belongs to a class of drugs called COX-2 inhibitors that block the production of an enzyme called cyclooxygenese–2 or simply COX-2. COX-2 triggers pain and inflammation in arthritis sufferers and may also fuel the growth of cancer.
"COX-2 inhibitors have emerged in recent years as a promising anticancer therapy. Many cancers have high levels of COX-2," explains Athanassios Argiris, M.D., an oncologist at Northwestern Memorial Hospital. Dr. Argiris, who coordinates the clinical research in lung as well as head and neck cancer at the Robert H. Lurie Comprehensive Cancer Center, is the principal investigator of the research study, which is also expected to open in other major institutions in the U.S. in the coming months. COX-2 may promote the growth of new blood vessels that nourish the cancer tumors. "Taking Celebrex may starve the tumor of nutrients in a process called anti-angiogenesis," he says. "It also appears to promote self-destruction of cancer cells."
Amanda Widtfeldt | EurekAlert!
'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS
New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
20.02.2018 | Life Sciences
20.02.2018 | Life Sciences
20.02.2018 | Physics and Astronomy