A research study under way at Northwestern Memorial Hospital is trying to find out if the popular anti-inflammatory drug Celebrex might do more than ease arthritis pain. Researchers at Northwestern Memorial are enrolling patients with early stage head and neck cancers or non-small cell lung cancers in a research study to see if Celebrex reduces the return of old tumors or the chance of getting a new cancer when taken after surgery or radiation treatments.
The double-blind, randomized study will enroll about 120 patients at Northwestern Memorial, the primary teaching hospital of Northwestern Universitys Feinberg School of Medicine. Celebrex belongs to a class of drugs called COX-2 inhibitors that block the production of an enzyme called cyclooxygenese–2 or simply COX-2. COX-2 triggers pain and inflammation in arthritis sufferers and may also fuel the growth of cancer.
"COX-2 inhibitors have emerged in recent years as a promising anticancer therapy. Many cancers have high levels of COX-2," explains Athanassios Argiris, M.D., an oncologist at Northwestern Memorial Hospital. Dr. Argiris, who coordinates the clinical research in lung as well as head and neck cancer at the Robert H. Lurie Comprehensive Cancer Center, is the principal investigator of the research study, which is also expected to open in other major institutions in the U.S. in the coming months. COX-2 may promote the growth of new blood vessels that nourish the cancer tumors. "Taking Celebrex may starve the tumor of nutrients in a process called anti-angiogenesis," he says. "It also appears to promote self-destruction of cancer cells."
Amanda Widtfeldt | EurekAlert!
Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital
New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
08.12.2017 | Event News
07.12.2017 | Event News
05.12.2017 | Event News
11.12.2017 | Physics and Astronomy
11.12.2017 | Materials Sciences
11.12.2017 | Earth Sciences