Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tissue Engineered Bone Grows Strong

26.06.2003


By closely following nature’s blueprint, Toronto researchers have developed an innovative way to speed the healing of severe bone breaks, resulting in what may be the thickest tissue-engineered bone ever produced in the laboratory.


Osteofoam™ scaffold
Molly Shoichet and John E. Davies Research Laboratories (U. Toronto) BoneTec Corp.


Human Trabecular Bone
Molly Shoichet and John E. Davies Research Laboratories (U. Toronto) BoneTec Corp.



The new bone grows naturally without the addition of chemical growth stimulants, said Whitaker investigator Molly Shoichet, Ph.D., of the University of Toronto. The innovation is in the design of the synthetic scaffold that provides a framework for the growing tissue.

The design mimics the structure of natural bone so faithfully that some experts in the field cannot distinguish between the two when shown micrographs of each side-by-side, Shoichet said. The research was published in the June 15 issue of the Journal of Biomedical Materials Research Part A.


"The structure is very open and porous," she said. "There are large interconnections between the pores separated by struts, rather than solid walls."

Into this spongy matrix, the researchers drizzle bone marrow cells, which can differentiate into osteoblasts, the strong, mineral-like cells of mature bone. The marrow cells take up residence in the scaffold and begin growing and multiplying. As they mature, the scaffold itself dissolves.

"You don’t need growth factors to get the cells into the scaffold," Shoichet said. "The cells almost fall through it and get stuck along the way."

The scaffold, developed with coinvestigator John Davies of the University of Toronto, is made of poly(lactide-co-glycolide), a polymer used in sutures. The polymer is processed in a unique way to yield the open, sponge-like structure with pores more than 10 times larger than those that result from conventional processing.

Animal studies show that the scaffold provides an intricate framework for dense new bone growth while it slowly dissolves. In rabbits, strong new bone completely replaced the scaffold in about eight weeks.

For some time, tissue engineers have experimented with scaffolds that promote bone growth. Much of this work has relied on supplementing the cell culture with growth hormones or other stimulating chemicals. Shoichet demonstrates a simpler, more natural way to grow new bone.

"To the best of our knowledge, bone growth throughout such a volume has not been reported before in the literature," she said.

The University of Toronto has licensed the technology to BoneTec Corp. for commercial development under the trademark name of Osteofoam. Shoichet is a vice president of the company.

The Whitaker Foundation has supported Shoichet’s laboratory through a 1998 Biomedical Engineering Research Grant for research to encourage the regrowth of damaged nerve cells.


Contact:
Molly Shoichet molly@ecf.utoronto.ca, University of Toronto
Frank Blanchard frank@whitaker.org, The Whitaker Foundation

Frank Blanchard | The Whitaker Foundation
Further information:
http://www.whitaker.org/news/shoichet.html

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>