Scientists studying the brains of mice have discovered how the toxic protein that destroys the brain cells of Alzheimers patients enters the brain. When the researchers gave mice a drug that blocked the process, flow of the protein into the brain was virtually halted and existing accumulations of it in the brain plummeted by more than 70 percent. The results of the research will be published in the July 1 issue of Nature Medicine.
The new findings center on amyloid beta, a tiny protein molecule that accumulates over time to form tell-tale plaques in the brain tissue of Alzheimers patients. While various cells within the brain itself produce amyloid beta, that amount may be just the tip of the iceberg. Mounting evidence suggests that the bulk of amyloid beta is produced in cells throughout the body and gets circulated in the blood. The new study reveals for the first time how the protein gets from the blood into the brain, thwarting the brains elaborate filtration mechanism that normally keeps away toxins. In mice that had been genetically engineered to develop Alzheimers, the process ran wild, pouring amyloid beta into the brain at eight times the rate of healthy mice.
"For more than a decade weve known that this protein wreaks havoc in the brains of Alzheimers patients, but we havent known how it gets there or how to prevent it from getting there. This study answers both of those basic questions, and opens an entirely new avenue for the treatment of Alzheimers disease," said lead author Berislav Zlokovic, M.D., Ph.D., of the University of Rochester Medical Center.
Christopher DiFrancesco | EurekAlert!
New vaccine production could improve flu shot accuracy
25.07.2017 | Duke University
Chances to treat childhood dementia
24.07.2017 | Julius-Maximilians-Universität Würzburg
Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers
Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...
Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.
At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...
3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects
A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
21.07.2017 | Event News
19.07.2017 | Event News
12.07.2017 | Event News
25.07.2017 | Physics and Astronomy
25.07.2017 | Earth Sciences
25.07.2017 | Life Sciences