Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cancer could be caught before it develops

20.06.2003


An article published in the journal BMC Medical Informatics and Decision Making describes the creation of the first comprehensive listing and classification of precancers, drawn from the medical literature. Using this classification, the precancers have been organized into groups that share similar biologic profiles and, hopefully, similar treatments.



Precancers precede invasive cancers. They are localized changes in tissue – lesions - identifiable by their morphologic structure. During carcinogenesis, when normal cells are transformed into cancerous cells, it is possible to identify precancers. Treating or removing precancerous cells at this early stage could prevent the prolonged, painful treatment and deaths of cancer sufferers. According to the authors of the article,

”Premalignant lesions are arguably the most important disease entities of modern man. In theory, the successful treatment of precancers would result in the eradication of most human cancers.”


Despite their importance, until now there has been no attempt to produce a list of precancers, or to classify them according to their biological properties. Jules Berman of the National Cancer Institute at the NIH, and Donald Henson of George Washington University, Washington D.C., have produced a first draft of such a classification, which can be downloaded from http://65.222.228.150/jjb/presum.tar.gz.

Berman and Henson worked from the National Library of Medicine’s Unified Medical Language System (UMLS), extracting all of the terms relating to precancers from the ‘Metathesaurus’, and adding an additional 10% from their own knowledge. They identified 568 distinct precancer ‘concepts’, which have been described by over 4700 terms. Often one precancer is described in many different ways, and can have a number of terms that refer to it. The database includes terms from seven languages in addition to English terms.

Precancer concepts and their associated terms were then grouped into six classes, defined by the authors, according to their biological properties. Berman and Henson provide, in the journal article, an in-depth description of precancer, along with the typical characteristics of each class of precancer.

The classification is designed to be fully searchable and linked to other databases. Written in XML (eXtensible Mark-up Language), it was converted into a HTML file so that it can be viewed in a standard Internet browser.

The authors recognize that this first draft is by no means definitive, so have posted the classification publicly and invited review by the medical community

Grace Baynes | alfa
Further information:
http://www.biomedcentral.com/1472-6947/3/8/

More articles from Health and Medicine:

nachricht Improving memory with magnets
28.03.2017 | McGill University

nachricht Graphene-based neural probes probe brain activity in high resolution
28.03.2017 | Graphene Flagship

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Transport of molecular motors into cilia

28.03.2017 | Life Sciences

A novel hybrid UAV that may change the way people operate drones

28.03.2017 | Information Technology

NASA spacecraft investigate clues in radiation belts

28.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>