Acrylamide, a possible human carcinogen that has been found in a variety of fried and starch-based foods, appears to exert its mutagenicity (the capacity to induce mutations) by forming DNA adducts and introducing genetic mutations, according to a study in the June 18 issue of the Journal of the National Cancer Institute. DNA adducts can interfere with the DNA replication process and lead to mutations and, in theory, to tumor formation.
Exposure to acrylamide has been shown to increase the incidence of a variety of cancers in rats and mice. Although no one knows how this process works, one theory is that acrylamide triggers mutagenesis by damaging DNA.
Ahmad Besaratinia, Ph.D., and Gerd P. Pfeifer, Ph.D., of the Beckman Research Institute of the City of Hope National Medical Center in Duarte, Calif., tested this hypothesis in mammalian cells in vitro by exposing mouse embryonic fibroblasts (connective tissue cells) that carried an artificially inserted gene known as a transgene to either acrylamide or a control, double-distilled water.
Linda Wang | EurekAlert!
Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University
Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
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27.02.2017 | Interdisciplinary Research
27.02.2017 | Life Sciences