Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New herbal drug therapy effective in treating vascular dementia

11.06.2003


American Heart Association meeting report



For centuries, the herb Chinese gastrodine has been used in China to treat disorders such as dizziness, headache and even ischemic stroke. Research presented today at the American Heart Association’s Second Asia Pacific Scientific Forum shows treatment with a gastrodine compound granule is effective in improving impaired memory, orientation, language and other effects of stroke in patients who were diagnosed with mild to moderate vascular dementia (VaD) after their stroke.

Vascular dementia is one of the most common dementias ranked after Alzheimer’s disease. It’s a growing problem in China, with a prevalence of about one to three percent, similar to prevalence rates in the United States and Europe. Because some medications for the condition are very expensive for most patients in China, researchers focused on finding treatments that would be effective and less costly. Chinese herbal medicines not only are less expensive and have fewer side effects than standard chemical medications, but they are also more accepted by the Chinese people, according to lead researcher Jinzhou Tian, M.D., Ph.D., director of the Institute of Geriatrics, Beijing University of Chinese Medicine.


For this study, researchers selected the gastrodine compound granule. It’s extracted from tall gastrodia tuber plants and six other herbs and is the first of new herbal drugs in dementia to be tested in clinical trials. The 12-week, randomized, double-blind trial was done in Beijing Dongzhimen Hospital, one of the hospitals running the clinical trials between 1999 and 2002. Researchers identified 120 stroke patients (75 male 45 female) who were diagnosed with mild to moderate VaD lasting three months or more. All patients were assessed for VaD at baseline and randomly divided into two treatment groups. One group (70 patients) was given one bag of the gastrodine compound granule (2.6 milligram gastrodine) three times a day for 12 weeks. The second group (50 patients) was given 40 mg of Duxilâ (almitrine + raubasine) three times a day for 12 weeks. This is a drug used to treat stroke patients in China. Both the gastrodine compound granule and the Duxilâ granule were dissolved in hot water and given orally.

In the gastrodine group, there were significant increases of the average MMSE (mini-mental state exam) score compared to baseline scores (20.83 vs.18.96). In the areas of memory, orientation, calculation, and language, the MMSE showed similar improvement in both groups.

However, the gastrodine group showed a significant difference in the Blessed Behavioral Scale (BBS) score - including behavior, activities of daily living, and personality - between endpoint (15.72) and baseline (18.76), as well as at endpoint (17.08) in the Duxilâ group. A score greater than or equal to 16 is abnormal and a score less than 16 is normal. The gastrodine group also suffered fewer side effects. Researchers say combined results showed the gastrodine group improvement was 51.43 percent, with 16 of the 70 cases showing much improvement, 20 cases with some improvement, and 34 cases with no change. The improvement rate for patients treated with Duxilâ was 52 percent, with seven of the 50 cases showing much improvement, 19 cases with some improvement, and 24 cases with no change.

The study also found that the gastrodine treatment may increase regional cerebral blood flow in VaD patients, but Tian says further study is needed to determine other benefits. Researchers also say a study of six months or more is needed to further determine the clinical effectiveness of the gastrodine compound granule for treating mild to moderate VaD. Given the positive results in the areas of memory and behavior, they say further research into herbal therapies for VaD may also be warranted.

"Chemical drugs, such as cholinesterase inhibitors, are effective in the treatment of cognitive and memory function in dementia, but these drugs are expensive and have side effects," says Tian. "This study might result in doctors considering the use of herbal medications, such as gastrodine compound granules to supplement the treatment of mild and moderate cognitive impairment in primary care for the elderly with cerebral ischemic damage."


Co-authors are Aihua Zhu, Jing Shi, Junxiang Yin, Jian Zhong, Chengzhi Yang, Shuliang Peng, Xianfeng Liu and Yongyan Wang.

NR03-1078 (AP/Tian)
Abstract P177

Carole Bullock | EurekAlert!
Further information:
http://www.americanheart.org/

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>