Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers find treatments that preserve ovarian function in young women with cancer

04.06.2003


Two studies by researchers at The University of Texas M. D. Anderson Cancer Center have identified treatments that appear helpful in preserving ovarian function in pre-menopausal women with cancer.



The unrelated analyses, to be presented at different times during the annual meeting of the American Society of Clinical Oncology, are the first to focus on the desire of many younger patients with breast as well as other cancers to maintain fertility, as well as to protect their bones, hearts, and sexual functioning.

One study, led by Nuhad K. Ibrahim, M.D., associate professor of breast medical oncology, found that breast cancer patients who used a paclitaxel-based chemotherapy regimen may preserve ovarian function compared with patients treated just with standard chemotherapy.


The other analysis, conducted by Naoto Ueno, M.D., Ph.D., assistant professor of blood and marrow transplantation, concluded that patients treated with "mini" allogeneic transplants for a variety of cancers also had a significantly greater chance of protecting their ovaries compared to patients given high dose chemo- or chemoradiation therapy with transplant.

1. Substituting Taxol in Chemotherapy Regimen Preserves Ovarian Fun

A follow-up study of hundreds of pre-menopausal patients treated for early stage breast cancer at M. D. Anderson found that partial use of paclitaxel (TaxolTM) with standard adjuvant chemotherapy significantly improved a younger woman’s chance that she could regain her ovarian function.

The standard chemotherapy regimen, known as FAC, includes adriamycin and cyclophosphamide with or without 5-fluorouracil.

The analysis, culled from a larger study of 580 breast cancer patients, compared ovarian function and outcomes in younger women who received eight rounds of FAC versus patients who received four rounds of FAC followed by four rounds of paclitaxel.

In a group of 29 women who received just FAC treatment, 20 women (69 percent) had permanent loss of ovarian function, six women (21 percent) had a transient loss of ovarian function, and three patients (10 percent) never lost it. But in 59 women who had been treated with the "four plus four" regimen, 28 patients (47 percent) lost use of their ovaries, while 26 patients (44 percent) had a transient lost, and 5 patients (8 percent) never lost ovarian function.

Four women who used paclitaxel subsequently became pregnant, compared to just one patient treated only with FAC, reports Ibrahim.

The results are important because, at M. D. Anderson, up to half of all breast cancer patients treated are younger than 50 years old, says Ibrahim.

"This is not just an issue of fertility, but also of maintaining other healthy issues that are usually associated with premature menopause, such as osteoporosis, an increase of lipids in the blood stream and associated heart diseases, as well as sexual and cognitive health.

"If the clinical outcome between the patients treated with FAC alone or with FAC and paclitaxel is equivalent, then there is no reason not to offer the paclitaxel-based regimen for the patients who desire to preserve fertility, or to delay premature menopause," Ibrahim says.

2. Mini Transplants, Used to Treat Many Cancers, Can Save Ovaries

The second study found that in treating a variety of cancers with donor stem cell transplantation, use of low-dose chemotherapy was much better at preserving ovarian function than was high-dose chemotherapy.

The retrospective analysis included 3,945 patients who had received stem cell transplants between 1987 and 2001, and looked at the outcome of women younger than age 50 who were being treated for any malignancy other than breast or ovarian cancer.

Results show that of the 77 patients who received high-dose chemotherapy followed by stem cell transplantation, 79 percent lost ovarian function as seen in loss of their menstrual cycle. In contrast, 16 patients treated with low-dose chemotherapy and stem cell rescue (a so-called "mini-transplantation"), only 37.5 percent lost use of their ovaries.

"It’s very exciting to find a transplantation regimen that can protect a woman’s ovaries because this can truly be of benefit to our patients to improve long-term quality of life," says Ueno. "Of course, this can only be proven with a prospective trial, but it makes sense that a weaker regimen would be less toxic."

Mini transplants are most often used to treat leukemia, lymphoma and certain solid tumors.


Contact: Stephanie Dedeaux or Laura Sussman, (713) 792-0655


Laura Sussman | EurekAlert!

More articles from Health and Medicine:

nachricht Malaria Already Endemic in the Mediterranean by the Roman Period
27.07.2017 | Universität Zürich

nachricht Serious children’s infections also spreading in Switzerland
26.07.2017 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Physicists Design Ultrafocused Pulses

Physicists working with researcher Oriol Romero-Isart devised a new simple scheme to theoretically generate arbitrarily short and focused electromagnetic fields. This new tool could be used for precise sensing and in microscopy.

Microwaves, heat radiation, light and X-radiation are examples for electromagnetic waves. Many applications require to focus the electromagnetic fields to...

Im Focus: Carbon Nanotubes Turn Electrical Current into Light-emitting Quasi-particles

Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers

Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...

Im Focus: Flexible proximity sensor creates smart surfaces

Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.

At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

 
Latest News

Programming cells with computer-like logic

27.07.2017 | Life Sciences

Identified the component that allows a lethal bacteria to spread resistance to antibiotics

27.07.2017 | Life Sciences

Malaria Already Endemic in the Mediterranean by the Roman Period

27.07.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>