Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers find treatments that preserve ovarian function in young women with cancer

04.06.2003


Two studies by researchers at The University of Texas M. D. Anderson Cancer Center have identified treatments that appear helpful in preserving ovarian function in pre-menopausal women with cancer.



The unrelated analyses, to be presented at different times during the annual meeting of the American Society of Clinical Oncology, are the first to focus on the desire of many younger patients with breast as well as other cancers to maintain fertility, as well as to protect their bones, hearts, and sexual functioning.

One study, led by Nuhad K. Ibrahim, M.D., associate professor of breast medical oncology, found that breast cancer patients who used a paclitaxel-based chemotherapy regimen may preserve ovarian function compared with patients treated just with standard chemotherapy.


The other analysis, conducted by Naoto Ueno, M.D., Ph.D., assistant professor of blood and marrow transplantation, concluded that patients treated with "mini" allogeneic transplants for a variety of cancers also had a significantly greater chance of protecting their ovaries compared to patients given high dose chemo- or chemoradiation therapy with transplant.

1. Substituting Taxol in Chemotherapy Regimen Preserves Ovarian Fun

A follow-up study of hundreds of pre-menopausal patients treated for early stage breast cancer at M. D. Anderson found that partial use of paclitaxel (TaxolTM) with standard adjuvant chemotherapy significantly improved a younger woman’s chance that she could regain her ovarian function.

The standard chemotherapy regimen, known as FAC, includes adriamycin and cyclophosphamide with or without 5-fluorouracil.

The analysis, culled from a larger study of 580 breast cancer patients, compared ovarian function and outcomes in younger women who received eight rounds of FAC versus patients who received four rounds of FAC followed by four rounds of paclitaxel.

In a group of 29 women who received just FAC treatment, 20 women (69 percent) had permanent loss of ovarian function, six women (21 percent) had a transient loss of ovarian function, and three patients (10 percent) never lost it. But in 59 women who had been treated with the "four plus four" regimen, 28 patients (47 percent) lost use of their ovaries, while 26 patients (44 percent) had a transient lost, and 5 patients (8 percent) never lost ovarian function.

Four women who used paclitaxel subsequently became pregnant, compared to just one patient treated only with FAC, reports Ibrahim.

The results are important because, at M. D. Anderson, up to half of all breast cancer patients treated are younger than 50 years old, says Ibrahim.

"This is not just an issue of fertility, but also of maintaining other healthy issues that are usually associated with premature menopause, such as osteoporosis, an increase of lipids in the blood stream and associated heart diseases, as well as sexual and cognitive health.

"If the clinical outcome between the patients treated with FAC alone or with FAC and paclitaxel is equivalent, then there is no reason not to offer the paclitaxel-based regimen for the patients who desire to preserve fertility, or to delay premature menopause," Ibrahim says.

2. Mini Transplants, Used to Treat Many Cancers, Can Save Ovaries

The second study found that in treating a variety of cancers with donor stem cell transplantation, use of low-dose chemotherapy was much better at preserving ovarian function than was high-dose chemotherapy.

The retrospective analysis included 3,945 patients who had received stem cell transplants between 1987 and 2001, and looked at the outcome of women younger than age 50 who were being treated for any malignancy other than breast or ovarian cancer.

Results show that of the 77 patients who received high-dose chemotherapy followed by stem cell transplantation, 79 percent lost ovarian function as seen in loss of their menstrual cycle. In contrast, 16 patients treated with low-dose chemotherapy and stem cell rescue (a so-called "mini-transplantation"), only 37.5 percent lost use of their ovaries.

"It’s very exciting to find a transplantation regimen that can protect a woman’s ovaries because this can truly be of benefit to our patients to improve long-term quality of life," says Ueno. "Of course, this can only be proven with a prospective trial, but it makes sense that a weaker regimen would be less toxic."

Mini transplants are most often used to treat leukemia, lymphoma and certain solid tumors.


Contact: Stephanie Dedeaux or Laura Sussman, (713) 792-0655


Laura Sussman | EurekAlert!

More articles from Health and Medicine:

nachricht Nanoparticles as a Solution against Antibiotic Resistance?
15.12.2017 | Friedrich-Schiller-Universität Jena

nachricht Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>