Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Combination treatment saves voice in patients with laryngeal cancer

03.06.2003


Patients with cancer of the larynx are likely to retain their voice and avoid surgery if they are treated simultaneously with chemotherapy and radiotherapy, say investigators who have conducted a nationwide study.



The findings are so significant they should become the new standard of care for stage III and IV laryngeal cancer, says one of the study’s lead investigators, Moshe Maor, M.D., professor of radiation oncology at The University of Texas M. D. Anderson Cancer Center.

"There is no question that this is the best treatment option for those patients who can tolerate chemotherapy," says Maor, who presented results of the eight-year, 517-patient trial during a "Best in Oncology" special session at the annual meeting of the American Society of Clinical Oncology.


The cancer, which is diagnosed in about 8,000 patients a year, usually as a result of smoking, is traditionally treated with "induction" chemotherapy followed by radiotherapy. But this study found that this standard therapy, as well as the third tested treatment of radiotherapy alone, resulted in a significantly greater rate of surgery and removal of the voice box because of cancer recurrence.

Specifically, the number of surgeries two years after treatment in patients who were treated with chemotherapy and radiotherapy together was 21, compared to 43 in patients who were treated with standard therapy, and 49 in patients who had radiotherapy alone.

"We believe that when delivered together, chemotherapy sensitizes the tumor to the killing effects of radiation," says Maor.

Because results from the two inferior treatments were the same, Maor says, the study raises the question of whether chemotherapy, when used by itself before radiotherapy, offers any benefit at all.

"Our theory is that tumors that respond to chemotherapy will respond to radiation anyway," Maor says. "Thus chemotherapy does not have an additional benefit unless used at the same time as radiotherapy."


Contact: Laura Sussman or Stephanie Dedeaux, (713) 792-0655

Laura Sussman | EurekAlert!

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

Im Focus: Repairing defects in fiber-reinforced plastics more efficiently

Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.

Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Multiregional brain on a chip

16.01.2017 | Power and Electrical Engineering

New technology enables 5-D imaging in live animals, humans

16.01.2017 | Information Technology

Researchers develop environmentally friendly soy air filter

16.01.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>