Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New organ preservation solution easier to use

02.06.2003


University of Pittsburgh researchers report results of first U.S. comparison study at the American Transplant Congress



A new organ preservation solution offers comparable results to a solution currently in widespread use but it is more cost-effective and has several logistical advantages that makes it more practical for keeping donated livers viable before being transplanted, conclude University of Pittsburgh Medical Center (UPMC) researchers who performed the first U.S. study to compare outcomes between the two solutions.

Their results comparing Histidine-Tryptophan-Ketogluterate (HTK) solution to the University of Wisconsin (UW) solution for the preservation of livers before transplantation are to be presented at the American Transplant Congress, the joint scientific meeting of the American Society of Transplant Surgeons and the American Society of Transplantation. The scientific sessions are June 1 – 4 at the Marriott Wardman Park Hotel in Washington, D.C.


Preservation solutions are used to extend the period that an organ remains viable, starting from the time it is removed from the donor to the time it is transplanted into a recipient. Each organ has its own limitations for how long this period can be extended. With current technology, hearts and lungs can be preserved safely for four to six hours while livers can be preserved for about 12 to 18 hours. Kidneys have a shelf life of about 24 hours. Preservation solutions allow organs to be transported between donor hospitals and transplant centers and serve to cool the organ as well as prevent cellular swelling and biochemical injury, processes that influence the function and survival of the organ once transplanted.

According to Bijan Eghtesad, M.D., associate professor of surgery at the University of Pittsburgh’s Thomas E. Starzl Transplantation Institute, outcome measures looking at initial organ function, the incidence of primary nonfunction and other clinical measures were similar between the two solutions when 84 liver transplants using HTK were compared to 167 transplants using UW. The two groups were matched for age of the recipient and donor and for cold ischemia time, the period of time that a donor organ is without a blood supply.

However, HTK’s much lower viscosity, which is nearly identical to water, and its biochemical makeup offer certain advantages that make it more practical and easier to use. For instance, surgeons found it to penetrate the liver’s vessels and bile duct structures better.

"While further study is needed, we believe that this lower viscosity makes it a better solution to use for livers recovered from non-heart beating donors because of its ability to flush out any residual blood left behind in vessels by the sudden stoppage of the heart," explained Dr. Eghtesad. Of the 84 liver transplants using HTK in the Pittsburgh study, eight involved non-heart beating donors.

Because HTK contains much less potassium, high levels of which can cause cardiac arrest, surgeons had fewer concerns about traces of the solution presenting such risk.

HTK does not need to be stored or transported in cold storage as does UW solution, and no additional products are required when using it. In addition, the Pittsburgh study found there to be less wastage of the product due to the solution’s packaging.

A cost-analysis done by the Center for Organ Recovery and Education, the organ procurement organization that serves UPMC, indicated that HTK is also more cost effective than UW. Based on 160 cases, the projected annual savings is between $73,000 and $137,000, reports Dr. Eghtesad.

Since February 2002, HTK has been the solution routinely used at UPMC for all liver, kidney and pancreas transplants.

HTK was developed by German company Dr. Franz Kohler Chemie GmbH, located in Alsbach-Hahnlein, and is marketed in the United States as CustodiolÒ HTK Solution by Odyssey Pharmaceuticals Inc. of East Hanover, N.J. The U.S. Food and Drug Administration has approved its use for preservation of donor kidneys. A number of European transplant centers have extensive experience with HTK but it is not widely used in the United States at this time. UW solution is marketed as ViaSpanä by Barr Laboratories of Pamona, N.Y.


CONTACT:
Lisa Rossi (Cell 412-916-3315)
Michele Baum
PHONE: 412-647-3555
FAX: 412-624-3184
E-MAIL:
RossiL@upmc.edu
BaumMD@upmc.edu

Lisa Rossi | EurekAlert!
Further information:
http://www.upmc.edu/

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

Im Focus: Repairing defects in fiber-reinforced plastics more efficiently

Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.

Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Multiregional brain on a chip

16.01.2017 | Power and Electrical Engineering

New technology enables 5-D imaging in live animals, humans

16.01.2017 | Information Technology

Researchers develop environmentally friendly soy air filter

16.01.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>