Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New organ preservation solution easier to use

02.06.2003


University of Pittsburgh researchers report results of first U.S. comparison study at the American Transplant Congress



A new organ preservation solution offers comparable results to a solution currently in widespread use but it is more cost-effective and has several logistical advantages that makes it more practical for keeping donated livers viable before being transplanted, conclude University of Pittsburgh Medical Center (UPMC) researchers who performed the first U.S. study to compare outcomes between the two solutions.

Their results comparing Histidine-Tryptophan-Ketogluterate (HTK) solution to the University of Wisconsin (UW) solution for the preservation of livers before transplantation are to be presented at the American Transplant Congress, the joint scientific meeting of the American Society of Transplant Surgeons and the American Society of Transplantation. The scientific sessions are June 1 – 4 at the Marriott Wardman Park Hotel in Washington, D.C.


Preservation solutions are used to extend the period that an organ remains viable, starting from the time it is removed from the donor to the time it is transplanted into a recipient. Each organ has its own limitations for how long this period can be extended. With current technology, hearts and lungs can be preserved safely for four to six hours while livers can be preserved for about 12 to 18 hours. Kidneys have a shelf life of about 24 hours. Preservation solutions allow organs to be transported between donor hospitals and transplant centers and serve to cool the organ as well as prevent cellular swelling and biochemical injury, processes that influence the function and survival of the organ once transplanted.

According to Bijan Eghtesad, M.D., associate professor of surgery at the University of Pittsburgh’s Thomas E. Starzl Transplantation Institute, outcome measures looking at initial organ function, the incidence of primary nonfunction and other clinical measures were similar between the two solutions when 84 liver transplants using HTK were compared to 167 transplants using UW. The two groups were matched for age of the recipient and donor and for cold ischemia time, the period of time that a donor organ is without a blood supply.

However, HTK’s much lower viscosity, which is nearly identical to water, and its biochemical makeup offer certain advantages that make it more practical and easier to use. For instance, surgeons found it to penetrate the liver’s vessels and bile duct structures better.

"While further study is needed, we believe that this lower viscosity makes it a better solution to use for livers recovered from non-heart beating donors because of its ability to flush out any residual blood left behind in vessels by the sudden stoppage of the heart," explained Dr. Eghtesad. Of the 84 liver transplants using HTK in the Pittsburgh study, eight involved non-heart beating donors.

Because HTK contains much less potassium, high levels of which can cause cardiac arrest, surgeons had fewer concerns about traces of the solution presenting such risk.

HTK does not need to be stored or transported in cold storage as does UW solution, and no additional products are required when using it. In addition, the Pittsburgh study found there to be less wastage of the product due to the solution’s packaging.

A cost-analysis done by the Center for Organ Recovery and Education, the organ procurement organization that serves UPMC, indicated that HTK is also more cost effective than UW. Based on 160 cases, the projected annual savings is between $73,000 and $137,000, reports Dr. Eghtesad.

Since February 2002, HTK has been the solution routinely used at UPMC for all liver, kidney and pancreas transplants.

HTK was developed by German company Dr. Franz Kohler Chemie GmbH, located in Alsbach-Hahnlein, and is marketed in the United States as CustodiolÒ HTK Solution by Odyssey Pharmaceuticals Inc. of East Hanover, N.J. The U.S. Food and Drug Administration has approved its use for preservation of donor kidneys. A number of European transplant centers have extensive experience with HTK but it is not widely used in the United States at this time. UW solution is marketed as ViaSpanä by Barr Laboratories of Pamona, N.Y.


CONTACT:
Lisa Rossi (Cell 412-916-3315)
Michele Baum
PHONE: 412-647-3555
FAX: 412-624-3184
E-MAIL:
RossiL@upmc.edu
BaumMD@upmc.edu

Lisa Rossi | EurekAlert!
Further information:
http://www.upmc.edu/

More articles from Health and Medicine:

nachricht Chronic stress induces fatal organ dysfunctions via a new neural circuit
21.08.2017 | Hokkaido University

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Nagoya physicists resolve long-standing mystery of structure-less transition

21.08.2017 | Materials Sciences

Chronic stress induces fatal organ dysfunctions via a new neural circuit

21.08.2017 | Health and Medicine

Scientists from the MSU studied new liquid-crystalline photochrom

21.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>