Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New study uses genetic profiling to predict breast cancer patients’

02.06.2003


Researchers at the Breast Care Center at Baylor College of Medicine and The Methodist Hospital have developed a new test to predict which breast cancer tumors will respond to chemotherapy, potentially reducing unnecessary treatment for women with breast cancer, according to data presented at the American Society of Clinical Oncology annual meeting in Chicago.



Using novel DNA array technology, the study identified differences in the gene patterns from tumor samples that predict which patients would respond to treatment with the chemotherapy docetaxel, marketed under the brand name Taxotere by Aventis.

After studying pretreatment biopsies from 24 patients and their genes after treatment, results show that tumors responding to Taxotere show a different pattern than tumors that had not responded to drug therapy. In the study, 88 percent of the genes were correctly classified, said Dr. Jenny Chang, an assistant professor of medicine at Baylor. This study marks the first time microarray technology has been used to study breast cancer tumor response to a chemotherapeutic agent.


"We may have a clinically useful predictive test for chemotherapy sensitivity that may allow us to prioritize breast cancer treatment strategies based on their likelihood of success," said Chang. "This research, if validated, may lead to important advances in the treatment of breast cancer including reducing unnecessary treatment for some women, while optimizing therapy for others."

The team of investigators, led by Chang, studied thousands of genes with new DNA array technology, to find the differences between tumors that responded to Taxotere chemotherapy and those tumors that failed to respond. This finding confirmed that breast cancers are not all alike, and treatment can be tailored to individual tumors.

"We are trying not only to understand the disease, but also how a patient’s tumor may respond to a treatment even before we select a chemotherapy. As opposed to acquired resistance, which builds up with months of therapy, these results show that some women will be resistant to the drug from day one," Chang said. "Once confirmed in a larger study, this type of molecular profiling could have profound clinical applications in defining optimal treatment selection for each individual patient."

Chemotherapy, designed to eliminate cancer cells that have spread, is beneficial in reducing the risk of death in many patients with early breast cancer, but physicians have long had trouble figuring out which patients would benefit from the treatment, she said. As a result, some breast cancer patients needlessly receive chemotherapy after surgery. Chemotherapy can have serious side effects, including nausea, vomiting, hair loss, diarrhea, nerve damage and infections.

Stefanie Asin | EurekAlert!
Further information:
http://research.bcm.tmc.edu/

More articles from Health and Medicine:

nachricht A whole-body approach to understanding chemosensory cells
13.12.2017 | Tokyo Institute of Technology

nachricht Research reveals how diabetes in pregnancy affects baby's heart
13.12.2017 | University of California - Los Angeles Health Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

A whole-body approach to understanding chemosensory cells

13.12.2017 | Health and Medicine

Water without windows: Capturing water vapor inside an electron microscope

13.12.2017 | Physics and Astronomy

Cellular Self-Digestion Process Triggers Autoimmune Disease

13.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>