As more is learned about how cancer develops, scientists have begun designing new drugs that directly target cancer cells, leaving healthy ones intact. Having fewer side effects, some of these drugs work by blocking growth signaling processes within cancer cells, while others enlist the body’s immune system to recognize and mount an attack against the cancer cell. But regardless of how they work, most of these drugs are designed to treat a specific cancer and cannot be used to treat other tumor types.
Now, an early clinical trial at the Cedars-Sinai Medical Center has shown that an experimental drug called 2C4 (trade name is Omnitarg) was effective to shrink tumors in patients with several different types of cancer. The findings, presented at the 39th annual meeting of the American Society of Clinical Oncology in Chicago, may lead to a new way to treat various types of cancer.
"What’s interesting is that this drug effectively shrank tumors in several completely different types of cancer in early stage clinical trials," said David Agus, M.D., Research Director at the Cedars-Sinai Prostate Cancer Center and first author of the study. "This tells us that the drug targets a growth signaling pathway in cancer cells that is common in many solid tumors."
Kelli Stauning | Cedars-Sinai Medical Center
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