Genes found on region of Chromosome 1 may regulate behaviors including eating and anxiety
Anorexia nervosa is a serious and potentially lethal illness. It is characterized by the relentless pursuit of thinness, the obsessive fear of gaining weight and emaciation. It commonly begins during adolescence in girls and it runs in families. A number of traits, such as perfectionism, anxiety and obsessionality, contribute to a risk to develop anorexia.
The authors used a process called candidate gene association analysis to identify two genes from a region on the short arm chromosome 1, previously identified as likely to contain genes contributing to anorexia nervosa, that may contribute to the risk of developing anorexia nervosa. When the authors compared anorexia patients to control individuals, they found statistically significant association of sequence polymorphisms at these two genes to anorexia nervosa, with increasing risk to individuals carrying specific alleles for developing anorexia nervosa.
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