Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Two genes found to influence anorexia nervosa

13.05.2003


Genes found on region of Chromosome 1 may regulate behaviors including eating and anxiety



Anorexia nervosa is a serious and potentially lethal illness. It is characterized by the relentless pursuit of thinness, the obsessive fear of gaining weight and emaciation. It commonly begins during adolescence in girls and it runs in families. A number of traits, such as perfectionism, anxiety and obsessionality, contribute to a risk to develop anorexia.

The authors used a process called candidate gene association analysis to identify two genes from a region on the short arm chromosome 1, previously identified as likely to contain genes contributing to anorexia nervosa, that may contribute to the risk of developing anorexia nervosa. When the authors compared anorexia patients to control individuals, they found statistically significant association of sequence polymorphisms at these two genes to anorexia nervosa, with increasing risk to individuals carrying specific alleles for developing anorexia nervosa.


To perform the gene association analysis, the researchers focused on a region of the short arm of chromosome 1. Earlier studies by the same researchers found this region was likely to contain genes contributing to anorexia nervosa in families. The researchers used candidate gene analysis to investigate several genes in the chromosome 1 region, using both positional information and biological information about genes in this region to nominate three genes for detailed analysis. In the candidate gene association analysis, the researchers analyzed sequence polymorphisms in DNA samples from families with anorexia and other eating disorders and from individuals not affected with anorexia nervosa. Two genes in the chromosome 1 region, HTR1D, the gene that codes for the serotonin 1D receptor, and OPRD1, the gene that codes for the delta opioid receptor, demonstrated statistically significant association to anorexia nervosa.



ARTICLE: "Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptors display significant association to anorexia nervosa"

AUTHORS: Andrew Bergen, Marianne Van Den Bree, Meredith Yeager, Robert Welch, Kelly Ganjei, Kashif Haque, Silviu-alin Bacanu, Wade Berrettini, Dorothy Grice, David Goldman, Cynthia Bulik, Kelly Klump, Manfred Fichter, Katherine Halmi, Allan Kaplan, Michael Strober, Janet Treasure, Blake Woodside, Walter Kaye

AFFILIATIONS: Biognosis U.S., Inc. (Dissolved). From the Price Foundation Collaborative Group: University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213,USA, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104; USA, National Institute of Alcohol Abuse and Alcoholism, Rockville, MD, USA; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, 23298, USA, Department of Psychology, Michigan State University, East Lansing, MI 48824, Klinik Roseneck, Hospital for Behavioral Medicine, Munich, D-83209, Germany, New York Presbyterian Hospital-Westchester, Weill Medical College of Cornell University, White Plains, New York, 10605, USA, Department of Psychiatry, The Toronto Hospital, Toronto, M5S2C4 Canada, Neuropsychiatric Institute and Hospital, School of Medicine, University of California at Los Angeles, Los Angeles, 90024,USA, Institute of Psychiatry, Maudsley and Bethlehem Royal Hospital, London, England, SE58AF, UK, Eating Disorders Module, Western Psychiatric HTR1D and OPRD1 and Anorexia Nervosa Institute & Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 15213,USA. Currently at: 12Core Genotyping Facility, Advanced Technology Center, National Cancer Institute, Gaithersburg, MD 20877, Division of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom, 14Core Genotyping Facility, Advanced Technology Center, National Cancer Institute/SAIC, Gaithersburg, MD 20877.

Funding for the study was provided by the Price Foundation, which has provided financial support for the research team for over a decade, described at http://www.anbn.org.

For more information on how to participate in genetic studies for eating disorders, please call 1-888-895-3886 or visit the Web site at www.angenetics.org.

Citation source: Molecular Psychiatry 2003 Volume 8, number 4, pages 397-406.

Aimee Midei | EurekAlert!
Further information:
http://www.naturesj.com/mp/
http://www.anbn.org
http://www.angenetics.org

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>