Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Success of chemotherapy tied to genetics

07.05.2003


Genetics may play a role in the success of anti-cancer therapy, according to researchers at the Research Institute of the McGill University Health Centre (MUHC) and the Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis - Jewish General Hospital. Their study, published in today’s issue of Clinical Cancer Research, shows that some colorectal cancer patients with a particular gene mutation respond much better to therapy than those without this genetic change.



"Our findings are important," says Dr. Rima Rozen acting Scientific Director of the Research Institute of the MUHC and senior author. "They demonstrate that colorectal cancer patients who have a particular genetic change, the MTHFR variant, will respond better to fluoropyrimidine-based chemotherapy than those patients without this genetic mutation. This suggests that therapy should be individualized. Patients with the MTHFR variant should be identified and appropriate chemotherapy should be administered."

"This finding may provide hope to the 10% to 15% of colorectal cancer patients who have the MTHFR variant" says co-author Dr. Victor Cohen, oncologist at the Sir Mortimer B. Davis-Jewish General Hospital (JGH) and researcher at the JGH’s Lady Davis Institute (LDI) for Medical Research. "Although these are preliminary findings, they suggest these patients will respond well to fluoropyrimidine-based chemotherapy and consequently may have a better prognosis. Larger scale studies are needed to determine the long term consequence of having this gene variant."


"Perhaps as important, the MTHFR enzyme may be an important target to inhibit and thus sensitize the majority of patients to this chemotherapy," adds co-author Dr. Gerald Batist, oncologist at the JGH and researcher at the LDI.

Dr. Rima Rozen’s laboratory is currently conducting research to evaluate MTHFR as a novel target for anti-cancer chemotherapy.

Both Dr. Batist and Dr. Cohen are members of the Montreal Centre for Experimental Therapeutics in Cancer. Based at the JGH, this centre groups together scientific investigators from all of Quebec’s major universities, representing a major leap forward in the battle against cancer.

Colon and rectal cancers, referred to as colorectal cancer, are life-threatening tumors that develop in the large intestine. The Canadian Cancer Society estimates that 18 000 people will be diagnosed with the disease this year. Only lung cancer is responsible for more cancer deaths.

Drs. Rozen, Cohen and Batist, who are also professors in the Faculty of Medicine at McGill University, analyzed 43 patients with advanced colorectal cancer. All patients were administered fluoropyrimidine-based chemotherapy. Tumour progression and survival rate was recorded, and their DNA analyzed. The 26 patients with a copy of the MTHFR variant responded better to fluoropyrimidine-based chemotherapy than those without the variant.

This research was funded by Variagenics, Inc.

About the Research Institute of the MUHC The Research Institute of the McGill University Health Centre (MUHC) located in Montreal, Quebec, is Canada’s largest concentration of biomedical and health-care researchers. The institute has over 500 researchers, nearly 650 graduate and post-doctoral students and 306 laboratories devoted to research. The mission of the institute is to facilitate investigator-initiated and discovery-driven research that creates new knowledge. This research is inextricably linked to the clinical programs of the MUHC, a full service academic hospital for patients of all ages.

About the Lady Davis Institute for Medical Research The Lady Davis Institute for Medical Research (LDI) located in Montreal, Quebec, is the research arm of the Sir Mortimer B. Davis - Jewish General Hospital and has strong academic links with McGill University. The LDI occupies an important position among major biomedical research institutions in Canada because of major discoveries in AIDS research, Aging, Cancer and Human Genetics. The LDI is currently the second largest biomedical research institute in the Province of Quebec as measured by the total value of peer reviewed grants and awards recognized by the Fonds de la Recherche en Santé du Québec (FRSQ).

Christine Zeindler | EurekAlert!
Further information:
http://www.mcgill.ca/

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>