Genetics may play a role in the success of anti-cancer therapy, according to researchers at the Research Institute of the McGill University Health Centre (MUHC) and the Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis - Jewish General Hospital. Their study, published in todays issue of Clinical Cancer Research, shows that some colorectal cancer patients with a particular gene mutation respond much better to therapy than those without this genetic change.
"Our findings are important," says Dr. Rima Rozen acting Scientific Director of the Research Institute of the MUHC and senior author. "They demonstrate that colorectal cancer patients who have a particular genetic change, the MTHFR variant, will respond better to fluoropyrimidine-based chemotherapy than those patients without this genetic mutation. This suggests that therapy should be individualized. Patients with the MTHFR variant should be identified and appropriate chemotherapy should be administered."
"This finding may provide hope to the 10% to 15% of colorectal cancer patients who have the MTHFR variant" says co-author Dr. Victor Cohen, oncologist at the Sir Mortimer B. Davis-Jewish General Hospital (JGH) and researcher at the JGHs Lady Davis Institute (LDI) for Medical Research. "Although these are preliminary findings, they suggest these patients will respond well to fluoropyrimidine-based chemotherapy and consequently may have a better prognosis. Larger scale studies are needed to determine the long term consequence of having this gene variant."
Christine Zeindler | EurekAlert!
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Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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26.05.2017 | Life Sciences
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