Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Staph Infection Process Leading to B Cell Suicide Described for First Time

05.05.2003


Enhances Potential for Future Development of B-Cell Based Therapy for Lupus



Researchers at the University of California, San Diego—supported by the Alliance for Lupus Research and the National Institutes of Health—have for the first time described a method that Staphylococcus aureus (staph) infection uses to inactivate the body’s immune system. A protein produced by the staph bacteria causes previously healthy B cells—a specialized cell of the immune system—to commit suicide, a process called apoptosis. The research will be published in the May 5 issue of the Journal of Experimental Medicine and at http://www.jem.org/pap.shtml on April 28.

In the new study, the researchers found that SpA, a staph protein, functions as a B cell toxin in mice. The protein attaches to a receptor on B cells, eventually causing the B cells to turn on themselves in a suicide process.


Researchers believe that B cells play a major role in tissue damage that occurs in lupus. “By the targeted elimination of disease-causing B cells, properly dosed injections of SpA may have the potential to control the over-activity of the immune system that causes damage in autoimmune diseases like lupus and in certain cancers,” said Gregg Silverman, M.D., UCSD professor of medicine and senior author of the paper.

“The significance of Dr. Silverman’s research is that the discovery that injections of SpA limit the activity of B cells in animals allows us to proceed to the next step, to test the protein’s usefulness in people,” said John H. Klippel, MD, scientific director of the Alliance for Lupus Research, which funded this study. “If results hold true for people, SpA may eventually prove to be an effective treatment for lupus.”

In addition to Silverman, the study was conducted by the paper’s co-author Carl S. Goodyear, Ph.D., a UCSD postdoctoral researcher.

The study was funded by the National Institutes of Health and the Alliance for Lupus Research. The ALR was founded by Robert Wood Johnson IV, of the Johnson & Johnson healthcare family and owner of the NFL’s New York Jets, with the Arthritis Foundation to raise the profile and scope of lupus research. Since its inception in 1999, the Alliance has committed more than $24 million to research, and has made remarkable gains toward unlocking the mysteries of this disease. ALR directs 100 percent of funds raised to peer-reviewed research and scientific programs. It recently received the highest rating (four stars) from Charity Navigator, an independent resource that evaluates the effectiveness and financial health of more than 2,300 charities.

For more information on our press releases, contact:
Linda De Vito
The Graubard Group
(212) 966-9000
ldevito@graubardgroup.com

Linda De Vito | Alliance for Lupus Research
Further information:
http://www.lupusresearch.org
http://www.lupusresearch.org/press_may1.html
http://www.jem.org/pap.shtml

More articles from Health and Medicine:

nachricht Investigators may unlock mystery of how staph cells dodge the body's immune system
22.09.2017 | Cedars-Sinai Medical Center

nachricht Monitoring the heart's mitochondria to predict cardiac arrest?
21.09.2017 | Boston Children's Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Rainbow colors reveal cell history: Uncovering β-cell heterogeneity

22.09.2017 | Life Sciences

Penn first in world to treat patient with new radiation technology

22.09.2017 | Medical Engineering

Calculating quietness

22.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>