Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers Discover Effective Method For Killing Prostate Cancer Cells

30.04.2003


By blocking a protein key to prostate cancer cell growth, researchers at the Lombardi Cancer Center at Georgetown University have discovered a way to trigger extensive prostate cancer cell death. This finding opens a new window for developing targeted treatments aimed at destroying prostate cancer cells before they have the opportunity to grow or spread. The study is published in the April 29 online issue of the Journal of Biological Chemistry.



“By preventing the Stat5 protein from being active, we were able to effectively kill human prostate cells,” said Marja Nevalainen, MD, PhD, assistant professor of oncology at Georgetown University Medical Center. "It’s similar to using a weed killer -- poison ivy cannot take over the backyard if we don’t allow the leaves to breathe. If we stop this protein, which in turn stops the growth of prostate cancer cells, we are one step closer to managing the spread and growth of cancer in the prostate.”

Recent understanding of the correlation between prolactin, a hormone produced by male and female pituitary glands, and how it promotes growth of cells in the prostate led to this new study. Pioneering work by Dr. Nevalainen and colleagues established that prolactin serves as a local growth factor for prostate cells and that Stat5 is the specific signaling device for prolactin in prostate cells. In other words, Stat5 acts as an internal signaling device within the cell, receiving and sending messages of prolactin to the cell’s DNA.


In the new study, Nevalainen explored what happens if the activation of Stat5 in prostate cancer cells is blocked. Using human prostate cancer cell lines and viral gene delivery of an inhibitory mutant of Stat5, Nevalainen and her colleagues found that blocking the activity of this protein in prostate cancer cells will trigger extensive cell death.

“Once prostate cancer has metastasized, or spread, men have few treatment options other than chemotherapy and radiation,” said Nevalainen. “This finding could certainly lead to the development of new targeted therapeutics that can put the brakes on the growth of prostate cancer cells, allowing us to kill tumor cells, reduce the volume of tumors, and kill already metastasized cells.”

This study was funded by the National Cancer Institute (NCI).

Prostate cancer is the second leading cause of cancer death in men, exceeded only by lung cancer. According to the American Cancer Society, prostate cancer is the most common type of cancer found in American men, other than skin cancer. The ACS estimates that there will be about 220,900 new cases of prostate cancer in the United States in the year 2003. About 28,900 men will die of this disease. African-American men are disproportionately affected by the disease.

Lindsey Spindle | georgetown news
Further information:
http://www.georgetown.edu/gumc
http://gumc.georgetown.edu/communications/releases/release.cfm?ObjectID=274

More articles from Health and Medicine:

nachricht Research offers clues for improved influenza vaccine design
09.04.2018 | NIH/National Institute of Allergy and Infectious Diseases

nachricht Injecting gene cocktail into mouse pancreas leads to humanlike tumors
06.04.2018 | University of Texas Health Science Center at San Antonio

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

Im Focus: The Future of Ultrafast Solid-State Physics

In an article that appears in the journal “Review of Modern Physics”, researchers at the Laboratory for Attosecond Physics (LAP) assess the current state of the field of ultrafast physics and consider its implications for future technologies.

Physicists can now control light in both time and space with hitherto unimagined precision. This is particularly true for the ability to generate ultrashort...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Diamond-like carbon is formed differently to what was believed -- machine learning enables development of new model

19.04.2018 | Materials Sciences

Electromagnetic wizardry: Wireless power transfer enhanced by backward signal

19.04.2018 | Physics and Astronomy

Ultrafast electron oscillation and dephasing monitored by attosecond light source

19.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>