By blocking a protein key to prostate cancer cell growth, researchers at the Lombardi Cancer Center at Georgetown University have discovered a way to trigger extensive prostate cancer cell death. This finding opens a new window for developing targeted treatments aimed at destroying prostate cancer cells before they have the opportunity to grow or spread. The study is published in the April 29 online issue of the Journal of Biological Chemistry.
“By preventing the Stat5 protein from being active, we were able to effectively kill human prostate cells,” said Marja Nevalainen, MD, PhD, assistant professor of oncology at Georgetown University Medical Center. "It’s similar to using a weed killer -- poison ivy cannot take over the backyard if we dont allow the leaves to breathe. If we stop this protein, which in turn stops the growth of prostate cancer cells, we are one step closer to managing the spread and growth of cancer in the prostate.”
Recent understanding of the correlation between prolactin, a hormone produced by male and female pituitary glands, and how it promotes growth of cells in the prostate led to this new study. Pioneering work by Dr. Nevalainen and colleagues established that prolactin serves as a local growth factor for prostate cells and that Stat5 is the specific signaling device for prolactin in prostate cells. In other words, Stat5 acts as an internal signaling device within the cell, receiving and sending messages of prolactin to the cell’s DNA.
Lindsey Spindle | georgetown news
Monitoring the heart's mitochondria to predict cardiac arrest?
21.09.2017 | Boston Children's Hospital
Highly precise wiring in the Cerebral Cortex
21.09.2017 | Max-Planck-Institut für Hirnforschung
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
19.09.2017 | Event News
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21.09.2017 | Physics and Astronomy
21.09.2017 | Life Sciences
21.09.2017 | Health and Medicine