By blocking a protein key to prostate cancer cell growth, researchers at the Lombardi Cancer Center at Georgetown University have discovered a way to trigger extensive prostate cancer cell death. This finding opens a new window for developing targeted treatments aimed at destroying prostate cancer cells before they have the opportunity to grow or spread. The study is published in the April 29 online issue of the Journal of Biological Chemistry.
“By preventing the Stat5 protein from being active, we were able to effectively kill human prostate cells,” said Marja Nevalainen, MD, PhD, assistant professor of oncology at Georgetown University Medical Center. "It’s similar to using a weed killer -- poison ivy cannot take over the backyard if we dont allow the leaves to breathe. If we stop this protein, which in turn stops the growth of prostate cancer cells, we are one step closer to managing the spread and growth of cancer in the prostate.”
Recent understanding of the correlation between prolactin, a hormone produced by male and female pituitary glands, and how it promotes growth of cells in the prostate led to this new study. Pioneering work by Dr. Nevalainen and colleagues established that prolactin serves as a local growth factor for prostate cells and that Stat5 is the specific signaling device for prolactin in prostate cells. In other words, Stat5 acts as an internal signaling device within the cell, receiving and sending messages of prolactin to the cell’s DNA.
Lindsey Spindle | georgetown news
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Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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