By blocking a protein key to prostate cancer cell growth, researchers at the Lombardi Cancer Center at Georgetown University have discovered a way to trigger extensive prostate cancer cell death. This finding opens a new window for developing targeted treatments aimed at destroying prostate cancer cells before they have the opportunity to grow or spread. The study is published in the April 29 online issue of the Journal of Biological Chemistry.
“By preventing the Stat5 protein from being active, we were able to effectively kill human prostate cells,” said Marja Nevalainen, MD, PhD, assistant professor of oncology at Georgetown University Medical Center. "It’s similar to using a weed killer -- poison ivy cannot take over the backyard if we dont allow the leaves to breathe. If we stop this protein, which in turn stops the growth of prostate cancer cells, we are one step closer to managing the spread and growth of cancer in the prostate.”
Recent understanding of the correlation between prolactin, a hormone produced by male and female pituitary glands, and how it promotes growth of cells in the prostate led to this new study. Pioneering work by Dr. Nevalainen and colleagues established that prolactin serves as a local growth factor for prostate cells and that Stat5 is the specific signaling device for prolactin in prostate cells. In other words, Stat5 acts as an internal signaling device within the cell, receiving and sending messages of prolactin to the cell’s DNA.
Lindsey Spindle | georgetown news
Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital
New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
12.12.2017 | Physics and Astronomy
12.12.2017 | Earth Sciences
12.12.2017 | Power and Electrical Engineering