Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research sheds new light on why some prostate cancers become untreatable

28.04.2003


Three new studies by researchers at UC Davis Cancer Center provide new pieces to the puzzle of why some prostate cancers become resistant to androgen suppression therapy. The studies were presented Sunday afternoon at the 2003 annual meeting of the American Urological Association.



Of the nearly 190,000 men in the United States who develop prostate cancer every year, a substantial proportion will require androgen suppression therapy to reduce levels of male hormones -- a treatment that can shrink prostate cancers or slow their growth. Hormone suppression therapy eventually fails, however, as prostate cancer cells adapt to an androgen-depleted environment, a state known as androgen independence. When this happens, few treatment options remain.

Determining how androgen independence develops, and how the process can be derailed, is a chief focus of prostate cancer research at UC Davis. "If we could prevent androgen independence from happening, it would have a dramatic impact on treatment and outcomes for prostate cancer," says Ralph deVere White, chair of urology at UC Davis School of Medicine and Medical Center and director of the UC Davis Cancer Center.


Two of the studies presented Sunday report new information about p53’s role in androgen independence. Mutations in p53 are seen in two out of three prostate cancers that have developed androgen independence. In one of the studies, deVere White and his colleagues demonstrated that four particular p53 mutations -- G245S, R248W, R273C and R273H -- facilitate androgen-independent growth in human prostate cells. The researchers were able to grow the four mutant cell lines in androgen-free conditions both in cell culture and in female laboratory mice. In addition, the researchers successfully used siRNA technology to target an siRNA molecule to the R273H mutation and down-regulate (suppress) its activity -- suggesting that siRNA technology may have therapeutic value in the treatment of hormone-independent prostate cancer.

In a second study, Clifford G. Tepper and his colleagues used microarray technology to hunt for specific genes that contribute to androgen independence. They reported Sunday that over-expression of one gene, known as Id-1, is a feature of androgen-independent tumors with p53 mutations. In order to identify Id-1, the researchers profiled more than 12,000 genes. They found 21 that are over-expressed in cells harboring G245S, R248W, R273C or R273H. Further analysis singled out one, the Id-1 gene, which produces a protein known to suppress cell aging and promote tumor aggressiveness.

In the third study, Christopher Evans and his colleagues report development of the first in vivo neuroendocrine model to study the progression of prostate cancer cells from androgen dependence to androgen independence. Using the model, the researchers demonstrated that neuroendocrine differentiation contributes to androgen-independent prostate cancer growth, proliferation and migration in an androgren-free environment.


UC Davis Cancer Center, the only National Cancer Institute-designated center between San Francisco and Portland, Ore., is a program of the UC Davis School of Medicine and Medical Center.

Public Affairs
UC Davis Health System
4900 Broadway, Suite 1200
Sacramento, CA 95820
Phone: (916) 734-9040
FAX: (916) 734-9056
E-mail: publicaffairs@ucdavis.edu


Claudia Morain | EurekAlert!
Further information:
http://news.ucdmc.ucdavis.edu

More articles from Health and Medicine:

nachricht Custom-tailored strategy against glioblastomas
26.09.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New leukemia treatment offers hope
23.09.2016 | King Abdullah University of Science and Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First quantum photonic circuit with electrically driven light source

Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.

Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

Im Focus: Complex hardmetal tools out of the 3D printer

For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.

Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...

Im Focus: Launch of New Industry Working Group for Process Control in Laser Material Processing

At AKL’16, the International Laser Technology Congress held in May this year, interest in the topic of process control was greater than expected. Appropriately, the event was also used to launch the Industry Working Group for Process Control in Laser Material Processing. The group provides a forum for representatives from industry and research to initiate pre-competitive projects and discuss issues such as standards, potential cost savings and feasibility.

In the age of industry 4.0, laser technology is firmly established within manufacturing. A wide variety of laser techniques – from USP ablation and additive...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Laser use for neurosurgery and biofabrication - LaserForum 2016 focuses on medical technology

27.09.2016 | Event News

Experts from industry and academia discuss the future mobile telecommunications standard 5G

23.09.2016 | Event News

ICPE in Graz for the seventh time

20.09.2016 | Event News

 
Latest News

New switch decides between genome repair and death of cells

27.09.2016 | Life Sciences

Nanotechnology for energy materials: Electrodes like leaf veins

27.09.2016 | Physics and Astronomy

‘Missing link’ found in the development of bioelectronic medicines

27.09.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>