Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Type 1 diabetics can get ’double diabetes’ from insulin resistance, says University of Pittsburgh

25.04.2003


Insulin resistance, a condition commonly associated with the development of type 2 diabetes, is likely a major cause of heart disease in people with type 1 diabetes, according to study results published by University of Pittsburgh Graduate School of Public Health (GSPH) researchers in the May 2003 issue of Diabetes Care, a journal of the American Diabetes Association.



"Heart disease is a major complication for people with diabetes, including those with type 1 diabetes, and until now there has been no clear explanation for its cause," said principal investigator Trevor Orchard, M.D., professor and acting chair, department of epidemiology, GSPH. "We now suspect that insulin resistance occurs in those with type 1 diabetes in the same way as it does in those with type 2, essentially giving these individuals double diabetes and greatly increasing their risk of heart disease."

Insulin resistance, long associated with type 2 diabetes and a known risk factor for heart disease, occurs when the body does not properly use insulin to metabolize blood glucose, or sugar. The condition results when insulin fails to enable cells to admit glucose, necessary for cells’ energy production. Glucose then builds up in the blood, and additional insulin is required. The new study suggests that this condition can occur in people who have type 1 diabetes as well.


"The good news is that not all people with type 1 diabetes are insulin resistant, and for them the risk of heart disease may not be as high," Dr. Orchard said. "Clearly, reducing or preventing insulin resistance through exercise, weight loss and possibly medication may help people with type 1 diabetes avoid heart disease."

The study analyzed data from the Pittsburgh Epidemiology of Diabetes Complication Study (PEDCS), a 10-year prospective investigation based on a cohort of adults with type 1, or childhood-onset, diabetes. Of the 658 subjects in PEDCS, 603 did not have heart disease at baseline and were followed for the current study.

Over the 10-year period there were 108 cardiovascular events such as angina, heart attack or death among the participants. Risk factors were lowest among those who experienced no cardiovascular events, moderate among those with angina and highest among those who died.

Insulin resistance was a risk factor that predicted all adverse events, and it was the most severe among those participants who experienced the most serious events.

To measure insulin resistance, investigators used the estimated glucose disposal rate (eGDR), a novel calculation based on waist-to-hip ratio, hypertension status and long-term blood sugar levels. Study participants with no cardiovascular events had a normal eGDR; those who experienced angina, considered a moderate event, had a lower eGDR; and those with the most severe events had the lowest eGDR.

High blood sugar itself was the only potential risk factor that did not appear to predict cardiovascular events.

"Our analyses are consistent with the hypothesis that individuals with high blood glucose develop plaques in their coronary arteries that are more fibrous than normal. That quality could have a stabilizing effect that makes the plaque less likely to rupture and cause a blood clot that would result in a heart attack," Dr. Orchard explained. "However, any protective effect from the fibrous nature of their arterial plaque is countered by the likelihood that glucose causes more such plaques and that it will not affect the risk of atherosclerosis-related problems elsewhere in the body, where the very existence of plaque can lead to lower extremity arterial disease, which sometimes results in amputation."

Kathryn Duda | EurekAlert!
Further information:
http://www.pitt.edu/~gsphhome

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>