Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Type 1 diabetics can get ’double diabetes’ from insulin resistance, says University of Pittsburgh


Insulin resistance, a condition commonly associated with the development of type 2 diabetes, is likely a major cause of heart disease in people with type 1 diabetes, according to study results published by University of Pittsburgh Graduate School of Public Health (GSPH) researchers in the May 2003 issue of Diabetes Care, a journal of the American Diabetes Association.

"Heart disease is a major complication for people with diabetes, including those with type 1 diabetes, and until now there has been no clear explanation for its cause," said principal investigator Trevor Orchard, M.D., professor and acting chair, department of epidemiology, GSPH. "We now suspect that insulin resistance occurs in those with type 1 diabetes in the same way as it does in those with type 2, essentially giving these individuals double diabetes and greatly increasing their risk of heart disease."

Insulin resistance, long associated with type 2 diabetes and a known risk factor for heart disease, occurs when the body does not properly use insulin to metabolize blood glucose, or sugar. The condition results when insulin fails to enable cells to admit glucose, necessary for cells’ energy production. Glucose then builds up in the blood, and additional insulin is required. The new study suggests that this condition can occur in people who have type 1 diabetes as well.

"The good news is that not all people with type 1 diabetes are insulin resistant, and for them the risk of heart disease may not be as high," Dr. Orchard said. "Clearly, reducing or preventing insulin resistance through exercise, weight loss and possibly medication may help people with type 1 diabetes avoid heart disease."

The study analyzed data from the Pittsburgh Epidemiology of Diabetes Complication Study (PEDCS), a 10-year prospective investigation based on a cohort of adults with type 1, or childhood-onset, diabetes. Of the 658 subjects in PEDCS, 603 did not have heart disease at baseline and were followed for the current study.

Over the 10-year period there were 108 cardiovascular events such as angina, heart attack or death among the participants. Risk factors were lowest among those who experienced no cardiovascular events, moderate among those with angina and highest among those who died.

Insulin resistance was a risk factor that predicted all adverse events, and it was the most severe among those participants who experienced the most serious events.

To measure insulin resistance, investigators used the estimated glucose disposal rate (eGDR), a novel calculation based on waist-to-hip ratio, hypertension status and long-term blood sugar levels. Study participants with no cardiovascular events had a normal eGDR; those who experienced angina, considered a moderate event, had a lower eGDR; and those with the most severe events had the lowest eGDR.

High blood sugar itself was the only potential risk factor that did not appear to predict cardiovascular events.

"Our analyses are consistent with the hypothesis that individuals with high blood glucose develop plaques in their coronary arteries that are more fibrous than normal. That quality could have a stabilizing effect that makes the plaque less likely to rupture and cause a blood clot that would result in a heart attack," Dr. Orchard explained. "However, any protective effect from the fibrous nature of their arterial plaque is countered by the likelihood that glucose causes more such plaques and that it will not affect the risk of atherosclerosis-related problems elsewhere in the body, where the very existence of plaque can lead to lower extremity arterial disease, which sometimes results in amputation."

Kathryn Duda | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>