Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Endostatin, radiation therapy combination stops blood vessel growth in mice

07.04.2003


Researchers report that in laboratory animals, the combination of radiation and the anti-angiogenic drug, endostatin, appears to work synergistically together to stop development of new blood vessels that seek to grow and nourish damaged tumors.


Researchers at The University of Texas M. D. Anderson Cancer Center found that the regrowth of new blood vessels was reduced five-fold in mice with implanted squamous cell cancer treated with radiation and endostatin compared to diseased mice that had radiation or endostatin alone, says Satoshi Itasaka, M.D., a visiting postdoctoral fellow from Kyoto, Japan.

"Endostatin enhanced the anti-tumor effects of irradiation and 40 percent of mice in the combined treatment group achieved long-term survival and tumor control," says Itasaka.

The researchers then examined the tumors and found that expression of crucial proteins varied among the treatment groups. Specifically, a "sharp" increase in VEGF/VPF, IL-8 and MMP2 proteins were found in tumors that had been irradiated. These proteins are proangiogenic and invasive factors that are needed to "signal" blood vessels to grow to tumor cells, to nourish them. Radiation increased levels of these proteins, but then endostatin "blocked" them from acting.



"After radiation, there is a regrowth of blood vessels as well as tumor cells, and endostatin seems to work to stop blood vessel regrowth," says Itasaka. "Why the combination of irradiation and endostatin works well is not fully understood yet, but it appears they may overcome the limitations of each other."

Other studies have looked at the effect of a combination of radiation and anti-angiogenesis drugs on death of blood vessel cells, but this is the first to examine whether these blood vessel cells regrow after irradiation, and what effect endostatin has on that regrowth, he says.

Laura Sussman | EurekAlert!

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

New pop-up strategy inspired by cuts, not folds

27.02.2017 | Materials Sciences

Sandia uses confined nanoparticles to improve hydrogen storage materials performance

27.02.2017 | Interdisciplinary Research

Decoding the genome's cryptic language

27.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>