Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Defect of cilia-assembly protein could cause most common genetic cause of kidney failure

01.04.2003


A protein responsible for the assembly of cell cilia – the hair-like projections from cells – may cause polycystic kidney disease, the most common genetic cause of kidney failure, according to a new study at UT Southwestern Medical Center at Dallas.



The study, which will be published online this week and will appear in a future edition of the Proceedings of the National Academy of Sciences, is the first to directly test the role of cilia in polycystic kidney disease. Previous studies have hinted at a possible link, said Dr. Peter Igarashi, chief of nephrology at UT Southwestern and senior author of the study.

"For a long time, renal cilia have been thought to be unimportant organelles," said Igarashi. "This study and others before it have renewed the interest in what cilia are doing normally and also how abnormalities in cilia cause disease."


Polycystic kidney disease (PKD) afflicts about one in every 500 people and causes fluid-filled cysts to accumulate in the kidney, liver and other organs. Formation of the cysts causes progressive renal failure, which requires dialysis or kidney transplantation. No other effective treatment is available.

To test whether stopping cilia formation causes PKD, researchers created knockout mice missing the gene Kif3, specifically in the kidneys. That gene codes for a motor protein that’s critical in cilia formation and maintenance. Researchers created kidney-specific knockouts because cilia are essential for embryonic development.

The knockout mice had normal kidneys at birth, but researchers found that kidney cysts began to develop about five days later and caused renal failure after about three weeks. Dissection by day 35 showed enlarged kidneys with multiple, fluid-filled cysts that had characteristics similar to cysts found in PKD.

"We are trying to understand the mechanism of cyst formation," said Dr. Fangming Lin, assistant professor of pediatrics and lead author of the study. "Once you understand the mechanism we will have the target to prevent or slow the cyst formation.

"That could eventually lead to a treatment of human polycystic disease."

Other UT Southwestern researchers who worked on the study were Dr. Thomas Hiesberger, assistant professor of internal medicine, and Kimberly Cordes, research assistant. Researchers from Yale University School of Medicine and the University of California, San Diego, School of Medicine also contributed to the study, which was funded by the National Institute of Diabetes and Digestive and Kidney Diseases.


###
To automatically receive news releases from UT Southwestern via e-mail, subscribe at http://lists.utsouthwestern.edu/mailman/listinfo/utswnews


Staishy Bostick Siem | EurekAlert!
Further information:
http://www.swmed.edu/

More articles from Health and Medicine:

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>