Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

OHSU scientists define adult stem cell healing abilities

31.03.2003


Research reveals how bone marrow-derived stem cells can be transformed into cells for the treatment of liver disease



Researchers at Oregon Health & Science University (OHSU) have explained how adult stem cells can heal diseased liver tissue. The research helps direct scientists in the quest for therapeutic uses of adult stem cells, which are derived from bone marrow. The research may also help define the therapeutic limits of these stem cells. The study results will be released online March 30 prior to being published in the journal Nature. The research was conducted in collaboration with Texas Children’s Hospital and Stem Cells Inc.

"Using mouse models, this research demonstrated that bone marrow-derived stem cells can combine with liver cells through a method known as cell fusion," explained Markus Grompe, M.D., a professor of molecular and medical genetics, and pediatrics in the OHSU School of Medicine. "This differs from earlier theories that adult stem cells can somehow be ’transformed’ into other cell types. The finding represents an important clarification on how adult stem cells can be transformed into therapeutically useful cells, capable of treating various diseases.


Cell fusion occurs when two or more cells combine to form one cell. The resulting cells contain more genetic material than normal. In a mouse model, for instance, fused liver cells may contain 80 chromosomes, double the amount found in a normal mouse liver cell.

To study the use of adult stem cells in treating liver disease, scientists at OHSU used a mouse model for a genetic disease called tyrosinemia, which causes severe liver damage. The research team used purified adult stem cells to treat these animals. While the transplanted cells resulted in a reversal of the liver damage, this reversal took place through cell fusion, not cell transformation.

Many recent reports have indicated that bone marrow stem cells can turn into other tissues such as brain, spinal cord, lung, intestine, pancreas or heart muscle. Although the OHSU research to date has demonstrated cell fusion only in liver, it is likely that cell fusion is responsible for many of these other cases of stem cell flexibility. The liver is able to heal using these cells. However, it’s possible that abnormal fused cells would not function in other regions of the body.

"While this research may help shift the focus of adult stem cell research, we also believe it’s a major step forward in utilizing stem cells to regenerate healthy liver cells in humans with liver disease," Grompe said. "The next step in this line of research would be to investigate whether there is a way to induce cell fusion, or speed up the fusion process, which is naturally quite slow and inefficient."

These results may also have applications in research for the burgeoning area of gene therapy. Scientists believe cell fusion may be a practical method for introducing new genetic material to correct mutated or malfunctioning genes that cause disease.


The National Institute of Diabetes and Digestive and Kidney Diseases, a component of the National Institutes of Health, funded this research.

Jim Newman | EurekAlert!
Further information:
http://www.ohsu.edu/

More articles from Health and Medicine:

nachricht Cholesterol-lowering drugs may fight infectious disease
22.08.2017 | Duke University

nachricht Once invincible superbug squashed by 'superteam' of antibiotics
22.08.2017 | University at Buffalo

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

What the world's tiniest 'monster truck' reveals

23.08.2017 | Life Sciences

Treating arthritis with algae

23.08.2017 | Life Sciences

Witnessing turbulent motion in the atmosphere of a distant star

23.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>