Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

OHSU scientists define adult stem cell healing abilities

31.03.2003


Research reveals how bone marrow-derived stem cells can be transformed into cells for the treatment of liver disease



Researchers at Oregon Health & Science University (OHSU) have explained how adult stem cells can heal diseased liver tissue. The research helps direct scientists in the quest for therapeutic uses of adult stem cells, which are derived from bone marrow. The research may also help define the therapeutic limits of these stem cells. The study results will be released online March 30 prior to being published in the journal Nature. The research was conducted in collaboration with Texas Children’s Hospital and Stem Cells Inc.

"Using mouse models, this research demonstrated that bone marrow-derived stem cells can combine with liver cells through a method known as cell fusion," explained Markus Grompe, M.D., a professor of molecular and medical genetics, and pediatrics in the OHSU School of Medicine. "This differs from earlier theories that adult stem cells can somehow be ’transformed’ into other cell types. The finding represents an important clarification on how adult stem cells can be transformed into therapeutically useful cells, capable of treating various diseases.


Cell fusion occurs when two or more cells combine to form one cell. The resulting cells contain more genetic material than normal. In a mouse model, for instance, fused liver cells may contain 80 chromosomes, double the amount found in a normal mouse liver cell.

To study the use of adult stem cells in treating liver disease, scientists at OHSU used a mouse model for a genetic disease called tyrosinemia, which causes severe liver damage. The research team used purified adult stem cells to treat these animals. While the transplanted cells resulted in a reversal of the liver damage, this reversal took place through cell fusion, not cell transformation.

Many recent reports have indicated that bone marrow stem cells can turn into other tissues such as brain, spinal cord, lung, intestine, pancreas or heart muscle. Although the OHSU research to date has demonstrated cell fusion only in liver, it is likely that cell fusion is responsible for many of these other cases of stem cell flexibility. The liver is able to heal using these cells. However, it’s possible that abnormal fused cells would not function in other regions of the body.

"While this research may help shift the focus of adult stem cell research, we also believe it’s a major step forward in utilizing stem cells to regenerate healthy liver cells in humans with liver disease," Grompe said. "The next step in this line of research would be to investigate whether there is a way to induce cell fusion, or speed up the fusion process, which is naturally quite slow and inefficient."

These results may also have applications in research for the burgeoning area of gene therapy. Scientists believe cell fusion may be a practical method for introducing new genetic material to correct mutated or malfunctioning genes that cause disease.


The National Institute of Diabetes and Digestive and Kidney Diseases, a component of the National Institutes of Health, funded this research.

Jim Newman | EurekAlert!
Further information:
http://www.ohsu.edu/

More articles from Health and Medicine:

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Scientist invents way to trigger artificial photosynthesis to clean air

26.04.2017 | Materials Sciences

Ammonium nitrogen input increases the synthesis of anticarcinogenic compounds in broccoli

26.04.2017 | Agricultural and Forestry Science

SwRI-led team discovers lull in Mars' giant impact history

26.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>