Research reveals how bone marrow-derived stem cells can be transformed into cells for the treatment of liver disease
Researchers at Oregon Health & Science University (OHSU) have explained how adult stem cells can heal diseased liver tissue. The research helps direct scientists in the quest for therapeutic uses of adult stem cells, which are derived from bone marrow. The research may also help define the therapeutic limits of these stem cells. The study results will be released online March 30 prior to being published in the journal Nature. The research was conducted in collaboration with Texas Childrens Hospital and Stem Cells Inc.
"Using mouse models, this research demonstrated that bone marrow-derived stem cells can combine with liver cells through a method known as cell fusion," explained Markus Grompe, M.D., a professor of molecular and medical genetics, and pediatrics in the OHSU School of Medicine. "This differs from earlier theories that adult stem cells can somehow be transformed into other cell types. The finding represents an important clarification on how adult stem cells can be transformed into therapeutically useful cells, capable of treating various diseases.
Jim Newman | EurekAlert!
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