Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

OHSU scientists define adult stem cell healing abilities

31.03.2003


Research reveals how bone marrow-derived stem cells can be transformed into cells for the treatment of liver disease



Researchers at Oregon Health & Science University (OHSU) have explained how adult stem cells can heal diseased liver tissue. The research helps direct scientists in the quest for therapeutic uses of adult stem cells, which are derived from bone marrow. The research may also help define the therapeutic limits of these stem cells. The study results will be released online March 30 prior to being published in the journal Nature. The research was conducted in collaboration with Texas Children’s Hospital and Stem Cells Inc.

"Using mouse models, this research demonstrated that bone marrow-derived stem cells can combine with liver cells through a method known as cell fusion," explained Markus Grompe, M.D., a professor of molecular and medical genetics, and pediatrics in the OHSU School of Medicine. "This differs from earlier theories that adult stem cells can somehow be ’transformed’ into other cell types. The finding represents an important clarification on how adult stem cells can be transformed into therapeutically useful cells, capable of treating various diseases.


Cell fusion occurs when two or more cells combine to form one cell. The resulting cells contain more genetic material than normal. In a mouse model, for instance, fused liver cells may contain 80 chromosomes, double the amount found in a normal mouse liver cell.

To study the use of adult stem cells in treating liver disease, scientists at OHSU used a mouse model for a genetic disease called tyrosinemia, which causes severe liver damage. The research team used purified adult stem cells to treat these animals. While the transplanted cells resulted in a reversal of the liver damage, this reversal took place through cell fusion, not cell transformation.

Many recent reports have indicated that bone marrow stem cells can turn into other tissues such as brain, spinal cord, lung, intestine, pancreas or heart muscle. Although the OHSU research to date has demonstrated cell fusion only in liver, it is likely that cell fusion is responsible for many of these other cases of stem cell flexibility. The liver is able to heal using these cells. However, it’s possible that abnormal fused cells would not function in other regions of the body.

"While this research may help shift the focus of adult stem cell research, we also believe it’s a major step forward in utilizing stem cells to regenerate healthy liver cells in humans with liver disease," Grompe said. "The next step in this line of research would be to investigate whether there is a way to induce cell fusion, or speed up the fusion process, which is naturally quite slow and inefficient."

These results may also have applications in research for the burgeoning area of gene therapy. Scientists believe cell fusion may be a practical method for introducing new genetic material to correct mutated or malfunctioning genes that cause disease.


The National Institute of Diabetes and Digestive and Kidney Diseases, a component of the National Institutes of Health, funded this research.

Jim Newman | EurekAlert!
Further information:
http://www.ohsu.edu/

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>