Research at Oxford University’s Institute of Molecular Medicine has identified a novel therapeutic regimen for the treatment of cancer that provides significant advantages over the existing methods of cancer treatment.
There are already a number of regimens available for treatment of cancer, including chemotherapy, which is commonly used to treat a number of different types of cancer. In most cases chemotherapeutic agents are given at the maximum tolerated dose (MTD), but at such doses the treatments can only be given in short courses and often have unacceptable side effects. In recent years, the use of immunotherapy for tumours has also increased, but tumour cells have been shown to evade immunotherapy by mutating to avoid presentation of the specific tumour epitope to the immune system. It has previously been suggested that a combination of immunotherapy and chemotherapy may prove effective as a treatment. However, this has not proved ideal since conventional chemotherapy suppresses the immune system, thereby reducing the effectiveness of the immunotherapy.
Researchers in Oxford have now devised a novel therapeutic regimen that combines the advantages of both chemotherapy and immunotherapy whilst reducing the disadvantages of each. It has been shown that chemotherapeutic agents can have a beneficial effect at doses lower than the MTD (such a dosing regimen has become known as metronomic dosing). Metronomic dosing, whilst not being as aggressive as the MTD regimen, has fewer side effects and can be used for longer periods without a break. The researchers have identified a metronomic regimen that does not cause the severe immunosuppression of standard chemotherapy and so opens the possibility of combining immunotherapy and chemotherapy. Furthermore, they have shown that such a combination therapy is more effective at inhibiting tumour growth than either chemotherapy (at MTD or as a metronomic dose), or immunotherapy alone or than immunotherapy in combination with chemotherapy at MTD.
Jennifer Johnson | alfa
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Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of light metals.
Scientists at the University of Stuttgart have now developed two new process variants that will considerably expand the areas of application for friction stir welding.
Technologie-Lizenz-Büro (TLB) GmbH supports the University of Stuttgart in patenting and marketing its innovations.
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Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.
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The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.
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With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.
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