Fox Chase Cancer Center researchers and their colleagues have developed a mouse model of the most prevalent and deadly form of human ovarian cancer -- epithelial ovarian cancer. The mouse model provides a better opportunity to study the cause of ovarian cancer, examine the genes involved and test preventive, diagnostic and treatment approaches that could be applied to human ovarian cancer.
"These transgenic mice offer us a valuable scientific tool that never before has been available to ovarian cancer researchers," explained Fox Chase Cancer Centers Denise C. Connolly, Ph.D., corresponding author of the study, which appears in the March 15, 2003, issue of Cancer Research, a journal of the American Association for Cancer Research.
The mice engineered by Connolly and her colleagues develop epithelial ovarian cancer in both ovaries. This cancer arises in the surface, or epithelial, cells of the ovaries. The mouse model was made by introducing a genetically engineered DNA fragment into fertilized mouse eggs prior to their embryonic development. The fragment is a combination of a gene specific promoter and a potent oncogene. The oncogene, Simian virus 40 T antigen, triggers cancer development. The promoter is derived from a gene (Mullerian inhibitory substance type II receptor) that signals the expression of a specific protein found in cells covering the ovaries.
Karen Mallet | EurekAlert!
'Exciting' discovery on path to develop new type of vaccine to treat global viruses
18.09.2017 | University of Southampton
A new approach to high insulin levels
18.09.2017 | Schweizerischer Nationalfonds SNF
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...
Scientists from the MPI for Chemical Energy Conversion report in the first issue of the new journal JOULE.
Cell Press has just released the first issue of Joule, a new journal dedicated to sustainable energy research. In this issue James Birrell, Olaf Rüdiger,...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
19.09.2017 | Event News
19.09.2017 | Physics and Astronomy
19.09.2017 | Power and Electrical Engineering