Defects in a protein called alphaV beta3 ntegrin appear to contribute to the development of osteoporosis, and these effects can be reversed by enhancing a protein called macrophage-colony-stimulating factor (M-CSF), according to research at Washington University School of Medicine in St. Louis.
The study appears in the first March issue of the Journal of Clinical Investigation and is published online March 4.
"Because of our previous research with these proteins, new drugs already are in clinical trials," says lead investigator Steven L. Teitelbaum, M.D., the Wilma and Roswell Messing Professor of Pathology and Immunology. "But we still do not understand how these proteins interact to affect bone-cell development. This study brings us significantly closer to determining that mechanism."
Gila Z. Reckess | EurekAlert!
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