DM2 more common than previously thought
Researchers at the University of Minnesota Medical School’s Muscular Dystrophy Center have developed the first reliable diagnostic test for myotonic muscular dystrophy type 2 (DM2), leading to the accurate determination of the disease’s clinical and molecular features. Initial results indicate that DM2 is much more common than previously thought, and may be one of the more common forms of muscular dystrophy. The findings will be reported in the Feb. 26 issue of Neurology.
Myotonic dystrophy (DM), the most common form of muscular dystrophy in adults, affects the eyes, heart, hormonal systems, and blood, in addition to causing muscular dystrophy and involuntary muscle stiffness (myotonia). Prior to this research, most cases of myotonic dystrophy were thought to be the more severe form, myotonic dystrophy type 1 (DM1), which occurs in about one of every 7,000 people worldwide. Earlier estimates that DM2 occurs at 2 percent of the rate for DM1 have now been significantly revised; the frequency of DM2 may equal that of DM1 in some populations.
Brenda Hudson | EurekAlert!
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