Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Shriners and MUHC investigate effects of oral steroids on the health of asthmatic children

25.02.2003


Parents concerned about use of oral steroids to treat their asthmatic children will be reassured by a new study conducted by a team of clinicians at the Research Institute of the McGill University Health Centre (MUHC) and the Shriners Hospital (Montreal). This study, the first to evaluate the effects of short courses of oral steroids on bone density and hormone function, was published in the February issue of the international journal Pediatrics.



“Often parents will be hesitant to administer prescribed oral glucocorticoids, a subset of steroids, to their asthmatic children because they are worried about the potential side effects,” says Dr. Francine Ducharme, pediatrician at the Montreal Children’s Hospital of the MUHC and lead author of the study. “These drugs are extremely effective at reducing inflammation of the airways and treating asthma flare-ups. This study shows that parents do not need to be concerned when these drugs are used for up to five days to treat acute asthma exacerbations.”

“One of the main concerns with glucocorticoid use is their effect on bones,” says Dr. Gilles Chabot, pediatrician at the Shriners Hospital and coauthor of the study. “We were able to look directly at the children’s bones and determine that the repeated short courses of oral glucocorticoids had no detectable cumulative negative effect on bone formation.”


The study compared the density of bones and the functioning of the adrenal gland, an organ that secretes natural steroids, of asthmatic children who received repeated short courses of oral glucocorticoids with those who were not prescribed the drugs. In total, 83 children were evaluated, some receiving as many as 11 short treatments in the course of 1 year. The findings showed that the glucocorticoids do not have lasting negative effects on bone metabolism and bone density, or on the functioning of the adrenal gland. In addition, there was no impact of the drugs on the children’s weight or height.

“Although this study does not address the effect of long term use of glucocorticoids, we hope that it may alleviate some concerns about the safety of using these very effective drugs over the short term,” says Dr. Ducharme.

“This is the first study to look at both hormonal function and bone health following exposure to glucocorticoids. This would not have been possible without the collaborative efforts between our institutions,” she concluded.


###
This study was supported by a grant from the National Health Research and Development Program of Canada.

For more information, please contact:
Arlette Côté, APR
Chief, Public Affairs Office
The Montreal Children’s Hospital
McGill University Health Centre

Christine Zeindler | EurekAlert!
Further information:
http://www.mcgill.ca/

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>