Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Knee ’scaffold’ study offers new hope for injury victims

13.02.2003


Scientists from the University of Leicester are taking revolutionary research further with the potential to offer new hope for knee-injury victims.



They are following up international research that aims to improve knee cartilage repair techniques, termed ‘chrondrocyte implantation’. The procedure, developed in Sweden ten years ago, involves growing a patient’s knee cartilage cells in a laboratory, which are then implanted through open knee surgery. Recent exciting developments revolve around the materials or ‘scaffolds’ that the cells are grown on. The scaffold is inserted into the knee with the seeded cells growing on it, and disintegrates slowly once the knee’s cartilage cells have become established.

Dr Paul Jenkins from the Department of Chemistry at the University of Leicester, and orthopaedic surgeon Dr Mike Harding from the University’s Department of Orthopaedic Surgery at Glenfield Hospital are collaborating to find the perfect biodegradeable polymer scaffold.


Dr Jenkins said: “We are using a polymer that is based on hyaluronic acid, which has great potential, because it degrades to an acid that is naturally present as a lubricant in all of our joints. The scaffold must be adhesive so that it stays in place inside the knee until enzymes in the knee degrade it. Probably the best known scaffold material is the benzyl ester of hyaluronic acid is extremely sticky when the chrondrocyte cells are growing in it. Our aim is to prepare and test new derivatives of hyaluronic acid to produce even better biodegradable matrix materials.”

Mr Harding said: “Cartilage tissue is mostly composed of a stiff, spongy matrix material produced by the cartilage cells. A property of the scaffold should be that it promotes the configuration of cartilage cells into the matrix shape. We are currently exploring the growth of cells onto different polymer scaffolds.”

The research is in the experimental stages, and has not yet been clinically tested. If the material proves to be a successful cartilage scaffold, extensive trials will be needed to allow it to be clinically tested for its reliability as a general surgical procedure for damaged knees.

Ather Mirza | alfa

More articles from Health and Medicine:

nachricht Correct connections are crucial
26.06.2017 | Charité - Universitätsmedizin Berlin

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Study shines light on brain cells that coordinate movement

26.06.2017 | Life Sciences

Smooth propagation of spin waves using gold

26.06.2017 | Physics and Astronomy

Switchable DNA mini-machines store information

26.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>