Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Knee ’scaffold’ study offers new hope for injury victims

13.02.2003


Scientists from the University of Leicester are taking revolutionary research further with the potential to offer new hope for knee-injury victims.



They are following up international research that aims to improve knee cartilage repair techniques, termed ‘chrondrocyte implantation’. The procedure, developed in Sweden ten years ago, involves growing a patient’s knee cartilage cells in a laboratory, which are then implanted through open knee surgery. Recent exciting developments revolve around the materials or ‘scaffolds’ that the cells are grown on. The scaffold is inserted into the knee with the seeded cells growing on it, and disintegrates slowly once the knee’s cartilage cells have become established.

Dr Paul Jenkins from the Department of Chemistry at the University of Leicester, and orthopaedic surgeon Dr Mike Harding from the University’s Department of Orthopaedic Surgery at Glenfield Hospital are collaborating to find the perfect biodegradeable polymer scaffold.


Dr Jenkins said: “We are using a polymer that is based on hyaluronic acid, which has great potential, because it degrades to an acid that is naturally present as a lubricant in all of our joints. The scaffold must be adhesive so that it stays in place inside the knee until enzymes in the knee degrade it. Probably the best known scaffold material is the benzyl ester of hyaluronic acid is extremely sticky when the chrondrocyte cells are growing in it. Our aim is to prepare and test new derivatives of hyaluronic acid to produce even better biodegradable matrix materials.”

Mr Harding said: “Cartilage tissue is mostly composed of a stiff, spongy matrix material produced by the cartilage cells. A property of the scaffold should be that it promotes the configuration of cartilage cells into the matrix shape. We are currently exploring the growth of cells onto different polymer scaffolds.”

The research is in the experimental stages, and has not yet been clinically tested. If the material proves to be a successful cartilage scaffold, extensive trials will be needed to allow it to be clinically tested for its reliability as a general surgical procedure for damaged knees.

Ather Mirza | alfa

More articles from Health and Medicine:

nachricht Vanishing capillaries
23.03.2017 | Technische Universität München

nachricht How prenatal maternal infections may affect genetic factors in Autism spectrum disorder
22.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short

23.03.2017 | Life Sciences

Researchers use light to remotely control curvature of plastics

23.03.2017 | Power and Electrical Engineering

Sea ice extent sinks to record lows at both poles

23.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>