Researchers in Oxford University’s Inorganic Chemistry Laboratory have found that they can intercalate a range of pharmaceutically active molecules between the layers of a layered inorganic host.
While working on the ion-exchange abilities of a family of inorganic materials known as Layered Double Hydroxides (LDHs), researchers have recognised that many commonly prescribed drugs and other over-the-counter medicines are either anions or can be conveniently and reversibly converted into an anion form. Research revealed that addition of one of these LDHs to a solution of a chosen pharmaceutical in water at room temperature results in intercalation of the these molecules between the sheets of the host structure. The LDHs are able to swell by up to 20Å to accommodate the size of the new guest molecules.
Certain drugs require controlled release and/or amelioration of side effects. LDHs already have medicinal properties in their own right as antacid and antipepsin agents. Propriety antacids products such as Talcid™ and Altacite™ contain the LDH [Mg6Al2(OH)16]CO3.
Jennifer Johnson | alfa
Usher syndrome: Gene therapy restores hearing and balance
25.09.2017 | Institut Pasteur
MRI contrast agent locates and distinguishes aggressive from slow-growing breast cancer
25.09.2017 | Case Western Reserve University
Graphene is up to the job
A warming planet
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
26.09.2017 | Life Sciences
26.09.2017 | Physics and Astronomy
26.09.2017 | Information Technology