Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Method of Controlled Drug Release

11.02.2003


Researchers in Oxford University’s Inorganic Chemistry Laboratory have found that they can intercalate a range of pharmaceutically active molecules between the layers of a layered inorganic host.



While working on the ion-exchange abilities of a family of inorganic materials known as Layered Double Hydroxides (LDHs), researchers have recognised that many commonly prescribed drugs and other over-the-counter medicines are either anions or can be conveniently and reversibly converted into an anion form. Research revealed that addition of one of these LDHs to a solution of a chosen pharmaceutical in water at room temperature results in intercalation of the these molecules between the sheets of the host structure. The LDHs are able to swell by up to 20Å to accommodate the size of the new guest molecules.

Certain drugs require controlled release and/or amelioration of side effects. LDHs already have medicinal properties in their own right as antacid and antipepsin agents. Propriety antacids products such as Talcid™ and Altacite™ contain the LDH [Mg6Al2(OH)16]CO3.


To date, the researchers have shown that compounds such Diclofenac, Ibuprofen, Naproxen, and Gemfibrozil intercalate rapidly into LDHs. The researchers are then able to quantitatively recover these molecules on demand. At the moment, drug release can be achieved by either dissolving the entire drug/LDH composite in dilute acid or by adding the drug/LDH to a phosphate buffer at pH 7. Preliminary kinetics experiments using phosphate buffers show that these drugs can be released back into solution in 1-3 hours at 37 °C.

Apart from the potential of using these materials to deliver drugs in vivo, the host itself could have additional benefits. It will be possible to control the point of release and pharmokinetic profile by selection of the metals ions in the host layers. The antacid performance and pH stability is also controllable by the choice of metal ions in the host layers. Confinement of the drugs between the metal’s layers restricts molecular interactions and dynamics and should improve long-term stability. Improved taste qualities of the formulation are also predicted.

Isis Innovation, Oxford University’s technology transfer company, has filed a UK priority patent application for this technology and welcomes contact from potential commercial partners.

Jennifer Johnson | alfa
Further information:
http://www.isis-innovation.com/licensing/957.html

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Strathclyde-led research develops world's highest gain high-power laser amplifier

The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.

The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Camera on NASA's Lunar Orbiter survived 2014 meteoroid hit

29.05.2017 | Physics and Astronomy

Strathclyde-led research develops world's highest gain high-power laser amplifier

29.05.2017 | Physics and Astronomy

A 3-D look at the 2015 El Niño

29.05.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>